Ngamsutham Thanunya, Chaiwong Warawut, Dacha Sauwaluk, Sitilertpisan Patraporn, Pothirat Chaicharn, Duangjit Pilaiporn, Deesomchok Athavudh, Liwsrisakun Chalerm, Bumroongkit Chaiwat, Theerakittikul Theerakorn, Limsukon Atikun, Trongtrakul Konlawij, Niyatiwatchanchai Nutchanok, Tajarernmuang Pattraporn
Division of Pulmonary, Critical Care, and Allergy, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
Tuberc Respir Dis (Seoul). 2024 Oct;87(4):532-542. doi: 10.4046/trd.2024.0044. Epub 2024 Aug 14.
The sequelae of post-coronavirus disease 2019 (COVID-19) pneumonia on lung function, exercise capacity, and quality of life were observed in both shortterm and long-term. However, the study about the respiratory and locomotor muscle strength in severe and critically ill COVID-19 survivors are still limited. Therefore, we aimed to examine long-term pulmonary function, functional capacities, and respiratory and locomotor body muscle strength in severe to critically ill post-COVID-19 survivors.
A prospective observational study was conducted in 22 post-COVID-19 pneumonia and healthy adults. Clinical characteristics during admission, pulmonary function, functional capacity, respiratory muscles, and locomotor muscles strength were examined at 1, 3, and 6 months after discharge from the hospital.
The generalized linear mixed model showed that percent predicted of forced expiratory volume in the 1 second (%FEV1), percent predicted of forced vital capacity (%FVC), maximum inspiratory pressure (MIP), handgrip strength, 6-minute walk distance, and five times sit to stand (5TSTS) were significantly lower in post-COVID-19 pneumonia patients than in healthy subjects during the follow-up period. The percent predicted of maximal voluntary ventilation (%MVV), and locomotor muscle strength were not different between the two groups throughout the follow-up period. Among post-COVID-19 pneumonia patients, %FEV1, %FVC, %MVV, 5TSTS, locomotor muscle strength significantly improved at three months compared to baseline at 1 month.
Pulmonary function, functional capacity, respiratory, and locomotor muscle strength of survivors from COVID-19 were impaired and recovery was observed after three to six months. These emphasized the need to evaluate the long-term consequences of COVID-19.
对2019冠状病毒病（COVID-19）肺炎患者肺功能、运动能力和生活质量的短期和长期后遗症均进行了观察。然而，关于重症和危重症COVID-19幸存者呼吸和运动肌肉力量的研究仍然有限。因此，我们旨在研究重症至危重症COVID-19康复患者的长期肺功能、功能能力以及呼吸和运动身体肌肉力量。
对22名COVID-19肺炎康复患者和健康成年人进行了一项前瞻性观察研究。在出院后1、3和6个月检查入院时的临床特征、肺功能、功能能力、呼吸肌肉和运动肌肉力量。
广义线性混合模型显示，在随访期间，COVID-19肺炎患者的1秒用力呼气容积预测值百分比（%FEV1）、用力肺活量预测值百分比（%FVC）、最大吸气压力（MIP）、握力、6分钟步行距离和五次坐立试验（5TSTS）均显著低于健康受试者。两组在整个随访期间的最大自主通气预测值百分比（%MVV）和运动肌肉力量没有差异。在COVID-19肺炎患者中，与1个月时的基线相比，%FEV1、%FVC、%MVV、5TSTS和运动肌肉力量在3个月时显著改善。
COVID-19康复患者的肺功能、功能能力、呼吸和运动肌肉力量受损，三至六个月后观察到恢复情况。这些强调了评估COVID-19长期后果的必要性。
