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血清转移RNA衍生片段的表达谱及其在非小细胞肺癌中的潜在作用。

Expression profiles of serum transfer RNA-derived fragments and their potential roles in non-small cell lung cancer.

作者信息

Song Yulan, Li Jipeng

机构信息

Blood Purification Center, The Affiliated People's Hospital of Ningbo University, Ningbo, China.

Department of Central Laboratory, The Affiliated People's Hospital of Ningbo University, Ningbo, China.

出版信息

Transl Cancer Res. 2024 Jul 31;13(7):3668-3677. doi: 10.21037/tcr-23-2364. Epub 2024 Jul 11.

DOI:10.21037/tcr-23-2364
PMID:39145073
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11322679/
Abstract

BACKGROUND

Non-small cell lung cancer (NSCLC) is one of the malignant tumors with the highest morbidity and mortality in the world. Early diagnosis can significantly improve the prognosis of patients. Transfer RNA (tRNA)-derived fragments (tRFs) have been found to have a crucial function in the pathophysiology of cancers. However, the role of tRFs/tRNA halves (tiRNAs) in NSCLC is yet unknown. The present study aimed to investigate unique expression profiles of tRFs/tiRNAs in NSCLC and search novel biomarkers for the diagnosis.

METHODS

RNA-sequencing was utilized for determining differently expressed tRFs/tiRNAs in serum in NSCLC and healthy controls. Stem-loop quantitative polymerase chain reaction (PCR) was used to confirm the selected tRFs/tiRNAs expressions. Their possible roles in NSCLC were predicted using bioinformatic research.

RESULTS

Eleven up-regulated tRFs/tiRNAs and 18 down-regulated tRFs/tiRNAs were determined. Levels of tRF-31-87R8WP9N1EWJ0 and tRF-31-79MP9P9NH57SD were significantly higher in NSCLC serum samples than those of healthy controls; the receiver operating characteristic (ROC) curve suggested that they could serve as new diagnostic biomarkers. Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis hinted that tRF-31-87R8WP9N1EWJ0 and tRF-31-79MP9P9NH57SD might influence the development and manifestation of NSCLC.

CONCLUSIONS

In NSCLC patients' serum, the tRFs/tiRNAs were abnormally regulated and that tRF-31-87R8WP9N1EWJ0 and tRF-31-79MP9P9NH57SD might be the potential biological markers for NSCLC.

摘要

背景

非小细胞肺癌（NSCLC）是全球发病率和死亡率最高的恶性肿瘤之一。早期诊断可显著改善患者预后。已发现转运RNA（tRNA）衍生片段（tRFs）在癌症病理生理学中起关键作用。然而，tRFs/tRNA半体（tiRNAs）在NSCLC中的作用尚不清楚。本研究旨在调查NSCLC中tRFs/tiRNAs的独特表达谱，并寻找新的诊断生物标志物。

方法

利用RNA测序确定NSCLC患者和健康对照血清中差异表达的tRFs/tiRNAs。采用茎环定量聚合酶链反应（PCR）确认所选tRFs/tiRNAs的表达。利用生物信息学研究预测它们在NSCLC中的可能作用。

结果

确定了11个上调的tRFs/tiRNAs和18个下调的tRFs/tiRNAs。NSCLC血清样本中tRF-31-87R8WP9N1EWJ0和tRF-31-79MP9P9NH57SD的水平显著高于健康对照；受试者工作特征（ROC）曲线表明它们可作为新的诊断生物标志物。基因本体（GO）富集和京都基因与基因组百科全书（KEGG）通路分析提示，tRF-31-87R8WP9N1EWJ0和tRF-31-79MP9P9NH57SD可能影响NSCLC的发生发展和表现。

结论

在NSCLC患者血清中，tRFs/tiRNAs存在异常调控，tRF-31-87R8WP9N1EWJ0和tRF-31-79MP9P9NH57SD可能是NSCLC的潜在生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e9c/11322679/c6c67d4c8d38/tcr-13-07-3668-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e9c/11322679/9f2b7d252823/tcr-13-07-3668-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e9c/11322679/62beabd203d1/tcr-13-07-3668-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e9c/11322679/b53cffe7e614/tcr-13-07-3668-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e9c/11322679/02fa125993e5/tcr-13-07-3668-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e9c/11322679/c6c67d4c8d38/tcr-13-07-3668-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e9c/11322679/9f2b7d252823/tcr-13-07-3668-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e9c/11322679/62beabd203d1/tcr-13-07-3668-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e9c/11322679/b53cffe7e614/tcr-13-07-3668-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e9c/11322679/02fa125993e5/tcr-13-07-3668-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e9c/11322679/c6c67d4c8d38/tcr-13-07-3668-f5.jpg

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