听觉和视觉白噪声对注意缺陷多动障碍儿童眼动抑制的影响：一项交叉研究方案。
Effects of Auditory and Visual White Noise on Oculomotor Inhibition in Children With Attention-Deficit/Hyperactivity Disorder: Protocol for a Crossover Study.
机构信息
Child and Adolescent Psychiatry, Department of Clinical Sciences, Lund University, Lund, Sweden.
Lund University Humanities Lab, Lund University, Lund, Sweden.
出版信息
JMIR Res Protoc. 2024 Aug 15;13:e56388. doi: 10.2196/56388.
BACKGROUND
In attention-deficit/hyperactivity disorder (ADHD), poor inhibitory control is one of the main characteristics, with oculomotor inhibition impairments being considered a potential biomarker of the disorder. While auditory white noise has demonstrated the ability to enhance working memory in this group, visual white noise is still unexplored and so are the effects of both types of white noise stimulation on oculomotor inhibition.
OBJECTIVE
This crossover study aims to explore the impact of auditory and visual white noise on oculomotor inhibition in children with ADHD and typically developing (TD) children. The study will investigate the impact of different noise levels (25% and 50% visual, 78 dB auditory), and performance will be evaluated both with and without noise stimulation. We hypothesize that exposure to white noise will improve performance in children with ADHD and impair the performance for TD children.
METHODS
Memory-guided saccades and prolonged fixations, known for their sensitivity in detecting oculomotor disinhibition in ADHD, will be used to assess performance. Children diagnosed with ADHD, withdrawing from medication for 24 hours, and TD children without psychiatric disorders were recruited for the study.
RESULTS
Data collection was initiated in October 2023 and ended in February 2024. A total of 97 participants were enrolled, and the first results are expected between September and November 2024.
CONCLUSIONS
This study will examine whether cross-modal sensory stimulation can enhance executive function, specifically eye movement control, in children with ADHD. In addition, the study will explore potential differences between auditory and visual noise effects in both groups. Our goal is to identify implications for understanding how noise can be used to improve cognitive performance.
TRIAL REGISTRATION
ClinicalTrials.gov NCT06057441; https://clinicaltrials.gov/study/NCT06057441.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/56388.
背景
在注意力缺陷/多动障碍（ADHD）中，抑制控制能力差是主要特征之一，眼球运动抑制损伤被认为是该障碍的潜在生物标志物。虽然听觉白噪声已被证明能够增强该人群的工作记忆，但视觉白噪声仍未被探索，两种类型的白噪声刺激对眼球运动抑制的影响也是如此。
目的
本交叉研究旨在探讨听觉和视觉白噪声对 ADHD 儿童和典型发育（TD）儿童眼球运动抑制的影响。该研究将探讨不同噪声水平（视觉 25%和 50%、听觉 78 dB）的影响，同时评估有无噪声刺激时的表现。我们假设暴露于白噪声会改善 ADHD 儿童的表现，而损害 TD 儿童的表现。
方法
记忆引导的眼球运动和延长的注视，已知在 ADHD 中检测眼球运动抑制不敏感，将用于评估表现。招募了被诊断为 ADHD 的儿童，他们停止用药 24 小时，且没有精神疾病的 TD 儿童参加了该研究。
结果
数据收集于 2023 年 10 月开始，2024 年 2 月结束。共纳入 97 名参与者，预计于 2024 年 9 月至 11 月间获得首批结果。
结论
本研究将检验跨模态感觉刺激是否可以增强 ADHD 儿童的执行功能，特别是眼球运动控制。此外，该研究将探讨两组中听觉和视觉噪声效应的潜在差异。我们的目标是确定理解噪声如何用于改善认知表现的意义。
试验注册
ClinicalTrials.gov NCT06057441；https://clinicaltrials.gov/study/NCT06057441。
国际注册报告标识符（IRRID）：DERR1-10.2196/56388。
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