Gregory H
J Cell Sci Suppl. 1985;3:11-7. doi: 10.1242/jcs.1985.supplement_3.2.
Recent evidence indicates that human urogastrone-epidermal growth factor originates in submandibular and Brunner's glands and that serum levels are low (less than 1 ng ml-1). It occurs in many secreted fluids to a much greater extent and many tissues are thus exposed to concentrations greater than 100 ng ml-1. Rapid actions in vivo of URO-EGF include the ability to inhibit gastric acid secretion at low doses (250 ng kg h-1 in humans) and to provide cytoprotective effects against ulcerogenic agents (250 ng kg h-1 in cats). More prolonged exposure of tissues shows increases in parameters related to wound healing, beneficial effects upon ulceration and also the ability to accelerate crypt cell production rate along the gastrointestinal tract. Synthetic material has been prepared with an identical structure to the natural URO-EGF thus enabling detailed studies of the biological effects to be pursued.
最近的证据表明，人尿抑胃素 - 表皮生长因子起源于下颌下腺和十二指肠腺，且血清水平较低（低于1 ng/ml）。它在许多分泌液中的含量要高得多，因此许多组织所接触到的浓度大于100 ng/ml。尿抑胃素 - 表皮生长因子在体内的快速作用包括低剂量时（人类为250 ng/kg·h）抑制胃酸分泌的能力，以及对致溃疡因子的细胞保护作用（猫为250 ng/kg·h）。组织更长时间的暴露显示与伤口愈合相关的参数增加，对溃疡有有益作用，并且能够加速胃肠道隐窝细胞的产生率。已经制备了与天然尿抑胃素 - 表皮生长因子结构相同的合成材料，从而能够对其生物学效应进行详细研究。
