Su C, Yang J, Yan F Z, Li L, Peng Z B, Zhang Y
Department of Infectious Diseases, Tianjin Center for Disease Control and Prevention, Tianjin 120011, China.
Division of Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2024 Aug 6;58(8):1124-1128. doi: 10.3760/cma.j.cn112150-20240117-00064.
To investigate the epidemiological characteristics of human respiratory syncytial virus (HRSV) in patients with Severe Acute Respiratory Infection (SARI) in Tianjin from 2015 to 2020. The study data were obtained from the Third Center Hospital of Tianjin, a designated sentinel hospital, from 2015 to 2020, with 1 597 SARI patients enrolled in this study. The clinical specimens of the research participants were subjected to respiratory multi-pathogen testing. HRSV-positive specimens were subtyped to analyze the differences in HRSV detection rates among cases of different age groups and periods and their mixed infection situations. A total of 1 597 nasopharyngeal swabs were collected, with an HRSV detection rate of 4.20%. Among 67 HRSV-positive specimens, there were 19 pure HRSV-A nucleic acid-positive specimens, 19 pure HRSV-B nucleic acid-positive specimens and 29 mixed HRSV-A and HRSV-B nucleic acid-positive specimens. The difference in HRSV detection rate among different age groups was statistically significant (<0.05), and the HRSV detection rate in children under five years old was higher than that in other age groups. From 2016 to 2020, the detection rate of HRSV showed an increasing trend year by year. The HRSV detection rate of SARI cases was highest in the winter season, at 7.15%. There were 10 (14.93%) mixed positive cases for HRSV and other viruses, of which four were mixed positive for HRSV and influenza A. The incidence of HRSV in Tianjin exhibits an increasing trend from 2016 to 2020, peaking during the winter season, with children under five years old constituting a high-risk demographic for HRSV infection.
调查2015年至2020年天津市重症急性呼吸道感染（SARI）患者中人类呼吸道合胞病毒（HRSV）的流行病学特征。研究数据来自天津市第三中心医院，这是一家指定的哨点医院，时间跨度为2015年至2020年，本研究共纳入1597例SARI患者。对研究参与者的临床标本进行呼吸道多病原体检测。对HRSV阳性标本进行亚型分析，以分析不同年龄组和时期病例中HRSV检出率的差异及其混合感染情况。共采集了1597份鼻咽拭子，HRSV检出率为4.20%。在67份HRSV阳性标本中，有19份单纯HRSV - A核酸阳性标本，19份单纯HRSV - B核酸阳性标本，29份HRSV - A和HRSV - B核酸混合阳性标本。不同年龄组的HRSV检出率差异有统计学意义（<0.05），五岁以下儿童的HRSV检出率高于其他年龄组。2016年至2020年，HRSV的检出率呈逐年上升趋势。SARI病例的HRSV检出率在冬季最高，为7.15%。有10例（14.93%）HRSV与其他病毒混合阳性病例，其中4例为HRSV与甲型流感混合阳性。2016年至2020年天津市HRSV发病率呈上升趋势，在冬季达到高峰，五岁以下儿童是HRSV感染的高危人群。
