Cui A L, Xia B C, Zhu Z, Xie Z B, Sun L W, Xu J, Xu J, Li Z, Zhao L Q, Long X R, Yu D S, Zhu B, Zhang F, Mu M, Xie H, Cai L, Zhu Y, Tian X L, Wang B, Gao Z G, Liu X Q, Ren B Z, Han G Y, Hu K X, Zhang Y
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases(NITFID)/NHC Key Laboratory of Medical Virology and Viral Diseases/National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Precision Medicine Research Center, Children's Hospital of Changchun, Changchun 130061, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2024 Jul 6;58(7):945-951. doi: 10.3760/cma.j.cn112150-20231213-00440.
To understand the epidemiological characteristics of human respiratory syncytial virus (HRSV) among acute respiratory infection (ARI) cases in 16 provinces of China from 2009 to 2023. The data of this study were collected from the ARI surveillance data from 16 provinces in China from 2009 to 2023, with a total of 28 278 ARI cases included in the study. The clinical specimens from ARI cases were screened for HRSV nucleic acid from 2009 to 2023, and differences in virus detection rates among cases of different age groups, regions, and months were analyzed. A total of 28 278 ARI cases were enrolled from January 2009 to September 2023. The age of the cases ranged from<1 month to 112 years, and the age (, ) was 3 years (1 year, 9 years). Among them, 3 062 cases were positive for HRSV nucleic acid, with a total detection rate of 10.83%. From 2009 to 2019, the detection rate of HRSV was 9.33%, and the virus was mainly prevalent in winter and spring. During the Corona Virus Disease 2019 (COVID-19) pandemic, the detection rate of HRSV fluctuated between 6.32% and 18.67%. There was no traditional winter epidemic peak of HRSV from the end of 2022 to the beginning of 2023, and an anti-seasonal epidemic of HRSV occurred from April to May 2023. About 87.95% (2 693/3 062) of positive cases were children under 5 years old, and the difference in the detection rate of HRSV among different age groups was statistically significant (<0.001), showing a decreasing trend of HRSV detection rate with the increase of age (<0.001). Among them, the HRSV detection rate (25.69%) was highest in children under 6 months. Compared with 2009-2019, the ranking of HRSV detection rates in different age groups changed from high to low between 2020 and 2023, with the age of HRSV positive cases increasing from 1 year (6 months, 3 years) to 2 years (11 months, 3 years). Through 15 years of continuous HRSV surveillance analysis, children under 5 years old, especially infants under 6 months old, are the main high-risk population for HRSV infection. During the COVID-19 pandemic, the prevalence and patterns of HRSV in China have changed.
了解2009年至2023年中国16个省份急性呼吸道感染（ARI）病例中人类呼吸道合胞病毒（HRSV）的流行病学特征。本研究数据收集自2009年至2023年中国16个省份的ARI监测数据，共纳入28278例ARI病例。对2009年至2023年ARI病例的临床标本进行HRSV核酸筛查，分析不同年龄组、地区和月份病例的病毒检出率差异。2009年1月至2023年9月共纳入28278例ARI病例。病例年龄范围为<1个月至112岁，年龄中位数为3岁（1岁，9岁）。其中，3062例HRSV核酸检测呈阳性，总检出率为10.83%。2009年至2019年，HRSV检出率为9.33%，该病毒主要在冬春季流行。在2019冠状病毒病（COVID-19）大流行期间，HRSV检出率在6.32%至18.67%之间波动。2022年底至2023年初没有传统的HRSV冬季流行高峰，2023年4月至5月出现了HRSV反季节流行。约87.95%（2693/3062）的阳性病例为5岁以下儿童，不同年龄组HRSV检出率差异有统计学意义（<0.001），显示HRSV检出率随年龄增长呈下降趋势（<0.001）。其中，6个月以下儿童的HRSV检出率最高（25.69%）。与2009 - 2019年相比，2020年至2023年不同年龄组HRSV检出率排名由高到低变化，HRSV阳性病例的年龄中位数从1岁（6个月，3岁）增加到2岁（11个月，3岁）。通过15年持续的HRSV监测分析，5岁以下儿童，尤其是6个月以下婴儿，是HRSV感染的主要高危人群。在COVID-19大流行期间，中国HRSV的流行情况和模式发生了变化。
