Sun Y, Wu W H, Huang Y L, Fang S S, Liu H, Jiang M, Meng J, Zou X, Wang X
Department of Pathogen Detection, Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2024 Aug 6;58(8):1117-1123. doi: 10.3760/cma.j.cn112150-20240318-00223.
To understand the epidemiological characteristics of human respiratory syncytial virus (HRSV) among cases presenting with influenza-like illness (ILI) in Shenzhen City from 2019 to 2023. Respiratory specimens were collected from two national sentinel hospitals in Shenzhen from March 2019 to December 2023, specifically targeting cases of ILI. The real-time PCR method was used for the detection and genotyping of HRSV. Basic demographic information was collected and used for the epidemiological analysis. A total of 9 278 respiratory specimens of influenza-like cases were collected and detected, with a total positive rate of 4.77% (443/9 278) for HRSV. In 2021 (8.48%, 167/1 970), the positive rate of HRSV was significantly higher than in 2019 (3.35%, 52/1 552), 2022 (1.80%, 39/2 169), and 2023 (4.49%, 133/2 960), and the difference was statistically significant (=102.395, <0.001). The prevalence of HRSV was mainly in summer and early autumn (September), and there was an abnormal increase in the positive rate of HRSV in winter 2022. The highest positive rate of HRSV was in children under five years old (9.84%, 330/335). The typing results showed that in 2022, the prevalence of HRSV-A was predominant (71.79%, 28/39), and in 2023, HRSV-A and HRSV-B subtypes coexisted. The prevalence of HRSV in Shenzhen from 2019 to 2023 has obvious seasonality, mainly in summer and early autumn. Children under five years old are the main population of HRSV infections.
了解2019年至2023年深圳市流感样病例（ILI）中人类呼吸道合胞病毒（HRSV）的流行病学特征。2019年3月至2023年12月期间，从深圳市两家国家级哨点医院收集呼吸道标本，专门针对ILI病例。采用实时荧光定量PCR方法对HRSV进行检测和基因分型。收集基本人口学信息并用于流行病学分析。共收集并检测了9278份流感样病例的呼吸道标本，HRSV总阳性率为4.77%（443/9278）。2021年HRSV阳性率（8.48%，167/1970）显著高于2019年（3.35%，52/1552）、2022年（1.80%，39/2169）和2023年（4.49%，133/2960），差异有统计学意义（=102.395，<0.001）。HRSV的流行主要集中在夏季和初秋（9月），2022年冬季HRSV阳性率出现异常升高。HRSV阳性率最高的是五岁以下儿童（9.84%，330/335）。分型结果显示，2022年HRSV-A的流行占主导（71.79%，28/39），2023年HRSV-A和HRSV-B亚型共存。2019年至2023年深圳市HRSV的流行具有明显的季节性，主要集中在夏季和初秋。五岁以下儿童是HRSV感染的主要人群。
