Su Xueshang, Zhuang Jun, Zhang Ziming, Wei Qingqian, Li Jingjing, Wang Zining, Jiang Liya, Hu Jintian
Department of Cosmetic Injection Center, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100144, People's Republic of China.
Department of Ear Reconstruction, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100144, People's Republic of China.
Aesthetic Plast Surg. 2025 Feb;49(4):1139-1144. doi: 10.1007/s00266-024-04311-8. Epub 2024 Aug 19.
Mesotherapy is a medical technique that administers cosmetic nutrients directly to the dermis through microdrop injections for aesthetic purposes. Its application has become increasingly widespread. However, there have also been a growing number of reported cases of multiple foreign body granulomas following mesotherapy. It is crucial to find an effective and safe treatment.
In this study, 31 patients with facial foreign body granuloma after mesotherapy were included. A mixture of 5-fluorouracil, lidocaine injection , and normal saline was prepared in a ratio of 1:1:4 and injected subcutaneously. Triamcinolone acetonide, 5-fluorouracil, lidocaine injection, and normal saline were prepared in a ratio of 2:5:3:10. Subcutaneous injections were administered to each papule using a 34G needle. The treatments were scheduled at intervals of 10-14 days. Color Doppler ultrasound was used to evaluate the condition before the initial treatment and after the final treatment.
The preoperative ultrasonography revealed diffuse hypoechoic areas in the dermis of the facial skin. After an average of 2-4 treatment sessions, a significant improvement was observed in all patients' appearance, with reduced redness and swelling, softened nodules, absence of pain and itching symptoms, and no evident abnormal echo on ultrasound examination. During a follow-up period ranging from 1 to 8 months, no recurrence or adverse reactions were reported.
This technique demonstrates clear efficacy. And this formulation effectively reduces the dosage of triamcinolone acetonide and minimizes the risk of adverse reactions such as skin atrophy. Therefore, it can be considered an effective treatment for multiple foreign body granulomas following mesotherapy.
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美塑疗法是一种通过微滴注射将美容营养物质直接注入真皮层以达到美容目的的医学技术。其应用日益广泛。然而，美塑疗法后出现的多发性异物肉芽肿报告病例也越来越多。找到一种有效且安全的治疗方法至关重要。
本研究纳入了31例美塑疗法后面部异物肉芽肿患者。将5-氟尿嘧啶、利多卡因注射液和生理盐水按1:1:4的比例混合，皮下注射。将曲安奈德、5-氟尿嘧啶、利多卡因注射液和生理盐水按2:5:3:10的比例配制。使用34G针头对每个丘疹进行皮下注射。治疗间隔为10 - 14天。在初始治疗前和最终治疗后使用彩色多普勒超声评估病情。
术前超声检查显示面部皮肤真皮层弥漫性低回声区。平均经过2 - 4次治疗后，所有患者的外观均有显著改善，红肿减轻，结节变软，疼痛和瘙痒症状消失，超声检查无明显异常回声。在1至8个月的随访期内，未报告复发或不良反应。
该技术显示出明显疗效。并且这种配方有效降低了曲安奈德的用量，将皮肤萎缩等不良反应的风险降至最低。因此，它可被认为是美塑疗法后多发性异物肉芽肿的有效治疗方法。
证据水平IV：本期刊要求作者为每篇文章指定证据水平。有关这些循证医学评级的完整描述，请参考目录或在线作者指南www.springer.com/00266 。
