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过去 15 年基于树突状细胞的疫苗的文献计量分析。

Bibliometric analysis of dendritic cell-based vaccines over the past 15 years.

机构信息

Department of Neurosurgery, Xiangya Hospital, Central South University, Jiangxi, China.

Hypothalamic-Pituitary Research Center, Xiangya Hospital, Central South University, Changsha, China.

出版信息

Hum Vaccin Immunother. 2024 Dec 31;20(1):2392961. doi: 10.1080/21645515.2024.2392961. Epub 2024 Aug 19.

Abstract

Dendritic cells, which are crucial for inducing T-cell responses, are pivotal in current immunotherapy strategies aiming to replenish depleted T cells within the tumor microenvironment to combat tumors. Consequently, dendritic cell vaccine-based cancer therapies have garnered significant attention. Through bibliometric analysis, we examined research trends in this field. We searched the Web of Science core database and identified 16,476 articles on dendritic cell-based vaccines published from January 1, 2009, to December 30, 2023. The United States leads in this research domain, with Emory University being a prominent collaborator. The Journal of Immunology is the primary publication outlet, and Banchereau, J emerges as the most influential author. Recent hot keywords include nanoparticle, delivery, cancer vaccine, and clinical trial, indicating that cancer immunotherapy research, especially dendritic cell-based vaccines, is poised to become a future trend and hotspot.

摘要

树突状细胞对于诱导 T 细胞反应至关重要,是当前免疫治疗策略的关键,旨在补充肿瘤微环境中耗尽的 T 细胞以对抗肿瘤。因此,基于树突状细胞的癌症疫苗治疗引起了广泛关注。通过文献计量分析,我们研究了该领域的研究趋势。我们在 Web of Science 核心数据库中进行了检索,确定了 2009 年 1 月 1 日至 2023 年 12 月 30 日期间发表的基于树突状细胞的疫苗的 16476 篇文章。美国在该研究领域处于领先地位,埃默里大学是一个突出的合作机构。《免疫学杂志》是主要的出版物,Banchereau,J 是最有影响力的作者。最近的热门关键词包括纳米颗粒、递送、癌症疫苗和临床试验,表明癌症免疫治疗研究,特别是基于树突状细胞的疫苗,有望成为未来的趋势和热点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bf5/11340764/10f83b30bb69/KHVI_A_2392961_F0001_B.jpg

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