Andrade Ana Luiza Cabral de Ávila, Pinto Yasmin Dias de Almeida, Maia Bernardo Emerenciano Barros, Corrêa Joice Dias, Miranda Diogo de Azevedo, Manzi Flávio Ricardo, Lima Izabella Lucas de Abreu
Department of Dentistry, Pontifical Catholic University of Minas Gerais, Belo Horizonte, Brazil.
Korean J Orthod. 2024 Sep 25;54(5):284-302. doi: 10.4041/kjod24.030. Epub 2024 Aug 20.
External apical root resorption (EARR) is characterized by permanent loss of dental structure at the root apex. This study aimed to systematically review gene polymorphisms associated with EARR in orthodontic patients.
Electronic database searches were performed across several databases.
This systematic review included 21 studies. Outcome measures were based on tooth dimensions observed on radiographs obtained before and after treatment. Polymorphisms in the following genes were genotyped using polymerase chain reaction-restriction fragment length polymorphism analysis: purinergic-receptor-P2X, ligand-gated ion channel 7 (), caspase-1/interleukin-converting enzyme (/), caspase-5 (), IL-1beta (), IL-1alpha (), interleukin-1 receptor antagonist gene (), tissue non-specific alkaline phosphatase (), tumor necrosis factor-alpha (), tumor necrosis factor receptor superfamily gene member 11a (), secreted phosphoprotein 1 (), tumor necrosis factor receptor superfamily gene member 11b (), interleukin 17A (), interleukin 6 (), receptor activator of nuclear factor-kappa B (), osteoprotegerin (), stromal antigen 2 (), vitamin D receptor (), cytochrome P450 family 24 subfamily A member 1 (), cytochrome P450 family 27 subfamily B (), group-specific component (), and interleukin-1 receptor-associated kinases 1 ().
Almost all studies suggested that IL1 gene is associated with EARR. Additionally, may be an important factor contributing to the etiopathogenesis of EARR. , , , , , , , , , / and have been identified in isolated studies. Further observational studies are needed to better explain the association between these genes and EARR.
根尖外吸收（EARR）的特征是根尖处牙体结构的永久性丧失。本研究旨在系统评价正畸患者中与EARR相关的基因多态性。
在多个数据库中进行电子数据库检索。
本系统评价纳入了21项研究。结局指标基于治疗前后获得的X线片上观察到的牙齿尺寸。使用聚合酶链反应-限制性片段长度多态性分析对以下基因的多态性进行基因分型：嘌呤能受体P2X、配体门控离子通道7（）、半胱天冬酶-1/白细胞介素转换酶（/）、半胱天冬酶-5（）、白细胞介素-1β（）、白细胞介素-1α（）、白细胞介素-1受体拮抗剂基因（）、组织非特异性碱性磷酸酶（）、肿瘤坏死因子-α（）、肿瘤坏死因子受体超家族基因成员11a（）、分泌型磷蛋白1（）、肿瘤坏死因子受体超家族基因成员11b（）、白细胞介素17A（）、白细胞介素6（）、核因子-κB受体激活剂（）、骨保护素（）、基质抗原2（）、维生素D受体（）、细胞色素P450家族24亚家族A成员1（）、细胞色素P450家族27亚家族B（）、组特异性成分（）和白细胞介素-1受体相关激酶1（）。
几乎所有研究均表明IL1基因与EARR相关。此外， 可能是EARR发病机制中的一个重要因素。在个别研究中已鉴定出 、 、 、 、 、 、 、 、 / 和 。需要进一步的观察性研究以更好地解释这些基因与EARR之间的关联。
