Lu Huiting, Zada Shah, Yang Lingzhi, Dong Haifeng
Department of Chemistry, School of Chemistry and Biological Engineering, University of Science & Technology Beijing, Beijing, China.
Marshall Laboratory of Biomedical Engineering Research Center for Biosensor and Nanotheranostic, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China.
Front Bioeng Biotechnol. 2022 Apr 21;10:851134. doi: 10.3389/fbioe.2022.851134. eCollection 2022.
The collection and analysis of biological samples are an effective means of disease diagnosis and treatment. Blood sampling is a traditional approach in biological analysis. However, the blood sampling approach inevitably relies on invasive techniques and is usually performed by a professional. The microneedle (MN)-based devices have gained increasing attention due to their noninvasive manner compared to the traditional blood-based analysis method. In the present review, we introduce the materials for fabrication of MNs. We categorize MN-based devices based on four classes: MNs for transdermal sampling, biomarker capture, detecting or monitoring analytes, and bio-signal recording. Their design strategies and corresponding application are highlighted and discussed in detail. Finally, future perspectives of MN-based devices are discussed.
生物样本的采集和分析是疾病诊断和治疗的有效手段。采血是生物分析中的传统方法。然而，采血方法不可避免地依赖侵入性技术，且通常由专业人员进行操作。与传统的基于血液的分析方法相比，基于微针（MN）的设备因其非侵入性方式而受到越来越多的关注。在本综述中，我们介绍了用于制造微针的材料。我们将基于微针的设备分为四类：用于经皮采样的微针、生物标志物捕获微针、检测或监测分析物的微针以及生物信号记录微针。重点突出并详细讨论了它们的设计策略和相应应用。最后，探讨了基于微针设备的未来前景。
