Li Jie, Xia Yi, Dai JianKun, Sun GuangYuan, Xu MeiLing, Lin XiaoQing, Gu LingLing, Shi Jie, Liu ShiYuan, Fan Li
College of Health Sciences and Engineering, University of Shanghai for Science and Technology, No.516 Jungong Road, Shanghai, 200093, China.
Department of Radiology, Second Affiliated Hospital of Naval Medical University, No. 415 Fengyang Road, Shanghai, 200003, China.
Heliyon. 2024 Jul 25;10(15):e35203. doi: 10.1016/j.heliyon.2024.e35203. eCollection 2024 Aug 15.
To compare the performance of SS, FOCUS SS, MUSE, and FOCUS MUSE DWI for pulmonary lesions to obtain a better technique for pulmonary DWI imaging.
44 patients with pulmonary lesions were recruited to perform pulmonary DWI using SS, FOCUS SS, MUSE, and FOCUS MUSE sequences. Then, two radiologists with 12 and 10 years of chest MRI experiences assessed the overall image quality while another two radiologists both with 3 years of experiences evaluated the SNR, DR, and ADC of pulmonary lesions. Using interclass correlation coefficient (ICC) and kappa statistics to assess consistency of readers, Friedman test and Dunn-Bonferroni post hoc were used to calculate the difference between sequences. Mann-Whitney test and ROC curve were used to distinguish malignant from benign lesions.
All the assessed variables of the four sequences presented good to excellent intra-/inter-observer consistency. Compared with SS, FOCUS SS and MUSE, FOCUS MUSE demonstrated better image quality, including significantly higher 5-point Likert scale score (P < 0.001) and smaller DR (P < 0.001). SNR was comparable among SS, FOCUS SS, and FOCUS MUSE (P > 0.05) while MUSE presented with significantly higher SNR over them (P < 0.01). ADC of malignant was significantly smaller than that of benign for all the four sequences (P < 0.05). ROC analysis showed relatively better diagnostic performance of FOCUS MUSE (AUC = 0.820) over SS (AUC = 0.748), FOCUS SS (AUC = 0.778), and MUSE (AUC = 0.729) in distinguishing malignant from benign lesions.
FOCUS MUSE possessed sufficient SNR and was better over SS, FOUCS SS, and MUSE for characterizing pulmonary lesions.
比较单次激发自旋回波（SS）、聚焦单次激发自旋回波（FOCUS SS）、多段采集自旋回波（MUSE）和聚焦多段采集自旋回波（FOCUS MUSE）扩散加权成像（DWI）对肺部病变的成像表现，以获得更好的肺部DWI成像技术。
招募44例肺部病变患者，使用SS、FOCUS SS、MUSE和FOCUS MUSE序列进行肺部DWI检查。然后，由两位分别具有12年和10年胸部MRI经验的放射科医生评估整体图像质量，另外两位均具有3年经验的放射科医生评估肺部病变的信噪比（SNR）、对比噪声比（DR）和表观扩散系数（ADC）。使用组内相关系数（ICC）和kappa统计量评估阅片者的一致性，采用Friedman检验和Dunn-Bonferroni事后检验计算序列之间的差异。采用Mann-Whitney检验和ROC曲线区分良恶性病变。
四个序列的所有评估变量在观察者内/观察者间均表现出良好至优秀的一致性。与SS、FOCUS SS和MUSE相比，FOCUS MUSE显示出更好的图像质量，包括显著更高的5级Likert量表评分（P < 0.001）和更小的DR（P < 0.001）。SS、FOCUS SS和FOCUS MUSE之间的SNR相当（P > 0.05），而MUSE的SNR显著高于它们（P < 0.
