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使用L.提取物介导的金纳米颗粒和导电纳米纤维用于心血管护理的超声绿色制剂的基本特性。

Fundamental characteristics of ultrasonic green formulations using L. extract-mediated gold nanoparticles and electroconductive nanofibers for cardiovascular nursing care.

作者信息

Wei Xinfang, Jiang Xiaoshan, Li Hongzan

机构信息

Department of Cardiovascular Medicine CCU, Zhongshan People's Hospital, No. 2 Sunwendong Road, Zhongshan City, Guangdong, 528403, China.

Department of Geriatrics, Qingdao Chengyang District People's Hospital, No. 600, Changcheng Road, Chengyang District, Qingdao, 266109, Shandong Province, China.

出版信息

Heliyon. 2024 Jul 25;10(15):e35018. doi: 10.1016/j.heliyon.2024.e35018. eCollection 2024 Aug 15.

DOI:10.1016/j.heliyon.2024.e35018
PMID:39170527
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11336310/
Abstract

In the pursuit of novel approaches to address chronic heart failure and enhance cardiovascular nursing care, environmentally sustainable nanomaterials have taken center stage. Recent progress in regenerative medicine has opened doors for the use of biocompatible biomaterials that provide mechanical support to damaged heart tissue and facilitate electrical signaling. This study was dedicated to developing advanced electroconductive nanofibers by incorporating eco-friendly L. extract-mediated gold nanoparticles (AuNPs) into polyaniline to create an intricate cardiac patch. The AuNPs were synthesized through an environmentally friendly chemical process aided by ultrasonic conditions. Comprehensive physicochemical analyses, such as UV-Vis spectroscopy, SEM, TEM, DPPH assay, and XRD, were carried out to characterize the AuNPs. These AuNPs were then blended with a polycaprolactone/gelatin polymeric solution and electrospun to fabricate cardiac patches, which underwent thorough evaluation using various techniques. The resulting cardiac patch demonstrated excellent hemocompatibility, antioxidant properties, and cytocompatibility, offering a promising therapeutic approach for myocardial infarctions and the advancement of cardiovascular nursing care.

摘要

在寻求解决慢性心力衰竭和加强心血管护理的新方法过程中，环境可持续的纳米材料已成为焦点。再生医学的最新进展为使用生物相容性生物材料打开了大门，这些材料可为受损心脏组织提供机械支持并促进电信号传导。本研究致力于通过将环保的L.提取物介导的金纳米颗粒（AuNPs）掺入聚苯胺中来开发先进的导电纳米纤维，以制造复杂的心脏贴片。AuNPs是通过在超声条件辅助下的环保化学过程合成的。进行了全面的物理化学分析，如紫外可见光谱、扫描电子显微镜、透射电子显微镜、DPPH测定和X射线衍射，以表征AuNPs。然后将这些AuNPs与聚己内酯/明胶聚合物溶液混合并静电纺丝以制造心脏贴片，并使用各种技术对其进行全面评估。所得的心脏贴片表现出优异的血液相容性、抗氧化性能和细胞相容性，为心肌梗死提供了一种有前景的治疗方法，并推动了心血管护理的发展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0573/11336310/52f29b4dcb7a/gr8.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0573/11336310/f1edafa471c3/gr4.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0573/11336310/eb7da5afc709/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0573/11336310/52f29b4dcb7a/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0573/11336310/2a05610c4435/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0573/11336310/f1882525938f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0573/11336310/b808f9dfd1b4/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0573/11336310/561b91533cca/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0573/11336310/f1edafa471c3/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0573/11336310/f14628f5f9b1/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0573/11336310/b000c8cd11e7/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0573/11336310/eb7da5afc709/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0573/11336310/52f29b4dcb7a/gr8.jpg

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