格雷夫斯眼病中抗人眼肌质膜自身抗体的检测
Measurement of autoantibodies against human eye muscle plasma membranes in Graves' ophthalmopathy.
作者信息
Faryna M, Nauman J, Gardas A
出版信息
Br Med J (Clin Res Ed). 1985 Jan 19;290(6463):191-2. doi: 10.1136/bmj.290.6463.191.
Abstract
Antibodies that reacted with plasma membranes of human eye muscle but showed no binding to plasma membranes of human skeletal muscle were identified in serum of patients with Graves' ophthalmopathy. Rabbit antithyroglobulin serum at a dilution of 1 X 10(-3) to 20 X 10(-3) had no effect on the binding of these antibodies to eye muscle membrane antigens. There was no correlation between antihuman eye muscle plasma membrane antibodies and antihuman thyroid membrane antibodies or antibodies against thyroglobulin. It is suggested that specific antibodies against eye muscle membranes are present in Graves' ophthalmopathy and that this disease might represent a distinct autoimmune disorder.
摘要
在格雷夫斯眼病患者的血清中发现了与人类眼肌质膜发生反应但不与人类骨骼肌质膜结合的抗体。稀释度为1×10⁻³至20×10⁻³的兔抗甲状腺球蛋白血清对这些抗体与眼肌膜抗原的结合没有影响。抗人类眼肌质膜抗体与抗人类甲状腺膜抗体或抗甲状腺球蛋白抗体之间没有相关性。提示格雷夫斯眼病中存在针对眼肌膜的特异性抗体，且该疾病可能代表一种独特的自身免疫性疾病。
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