牛淋巴细胞对布鲁氏菌流产亚种脂多糖的增殖反应。
Blastogenic response of bovine lymphocytes to Brucella abortus lipopolysaccharide.
作者信息
Baldwin C L, Winter A J
出版信息
Infect Immun. 1985 Feb;47(2):570-2. doi: 10.1128/iai.47.2.570-572.1985.
Abstract
Brucella abortus lipopolysaccharide was tested in a blastogenesis assay with unfractionated and nylon wool-separated peripheral blood lymphocytes of Brucella-naive cattle and cattle immunized with B. abortus. Our results indicated that in cattle the lipopolysaccharide of B. abortus is not a B-cell mitogen. In immunized animals it stimulated predominantly nylon wool-adherent cells. The lipopolysaccharide of Escherichia coli O128:B12, in contrast, induced a substantially greater proliferative response in circulating lymphocytes, predominantly those adherent to nylon wool, of the Brucella-naive cattle.
摘要
用流产布鲁氏菌脂多糖对未接触过布鲁氏菌的牛以及用流产布鲁氏菌免疫过的牛的未分级外周血淋巴细胞和经尼龙毛分离的外周血淋巴细胞进行了增殖试验。我们的结果表明，在牛中，流产布鲁氏菌的脂多糖不是B细胞促有丝分裂原。在免疫动物中，它主要刺激尼龙毛黏附细胞。相比之下，大肠杆菌O128:B12的脂多糖在未接触过布鲁氏菌的牛的循环淋巴细胞（主要是黏附于尼龙毛的淋巴细胞）中诱导出明显更强的增殖反应。
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