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患有注意力缺陷多动障碍(ADHD)的儿童与亚阈值ADHD儿童的不同表现。

Contrasting presentations of children with ADHD and subthreshold ADHD.

作者信息

He Lu, Zhao Yan, Gong Jin-Xin, Zhao Lu, Ma Zhou-Rui, Xiong Qian-Wei, Cai Shi-Zhong, Yan Xiang-Ming

机构信息

Department of Child and Adolescent Healthcare, Children's Hospital of Soochow University, Suzhou, China.

Department of Pediatrics, The Second Affiliated Hospital of Soochow University, Suzhou, China.

出版信息

Pediatr Res. 2024 Aug 24. doi: 10.1038/s41390-024-03502-y.

Abstract

BACKGROUND

We aimed to explore the differences and relationships in body composition, social function, and comorbidities between children with attention-deficit/hyperactivity disorder (ADHD) and subthreshold ADHD.

METHODS

A case-control study was conducted to analyze the differences between children with ADHD and subthreshold ADHD. Logistic regression models were used to analyze the factors influencing social functional impairments and comorbidities.

RESULTS

Children with ADHD and subthreshold ADHD had a higher fat mass index than healthy children (p < 0.05). The scores of all six social functional domains were higher in the subthreshold ADHD and ADHD groups than in the control group (p < 0.05). The prevalence of comorbidity was higher in children with subthreshold ADHD and ADHD compared to the control group (p < 0.05). Inattention and comorbid anxiety/depression increased the risk of functional impairments in children with ADHD (full syndrome/subthreshold), whereas a higher fat-free mass index reduced the risk. The severity of hyperactivity was associated with a higher risk of comorbidity in children with ADHD (full syndrome/subthreshold).

CONCLUSION

Children with subthreshold ADHD and ADHD had more fat mass and higher rates of social functional impairments and comorbidities than healthy children. There were clinical correlations between body composition, social functional impairments, and comorbidities in ADHD.

IMPACT

  1. Children with subthreshold ADHD and ADHD had higher fat mass levels than normal children. 2. The social function impairments and comorbidities of children with subthreshold ADHD were similar to those with ADHD. 3. Inattentiveness and anxiety/depression increased the risk of functional impairments in children with ADHD (full syndrome/subthreshold), while a higher fat-free mass index and skeletal muscle-to-body fat ratio reduced the risk.
摘要

背景

我们旨在探讨注意力缺陷多动障碍(ADHD)患儿与亚阈值ADHD患儿在身体成分、社会功能和合并症方面的差异及关系。

方法

进行一项病例对照研究,以分析ADHD患儿与亚阈值ADHD患儿之间的差异。采用逻辑回归模型分析影响社会功能障碍和合并症的因素。

结果

ADHD患儿和亚阈值ADHD患儿的脂肪质量指数高于健康儿童(p<0.05)。亚阈值ADHD组和ADHD组的所有六个社会功能领域得分均高于对照组(p<0.05)。与对照组相比,亚阈值ADHD患儿和ADHD患儿的合并症患病率更高(p<0.05)。注意力不集中和合并焦虑/抑郁增加了ADHD患儿(全综合征/亚阈值)功能障碍的风险,而较高的去脂体重指数则降低了该风险。多动严重程度与ADHD患儿(全综合征/亚阈值)合并症风险较高相关。

结论

亚阈值ADHD患儿和ADHD患儿比健康儿童有更多的脂肪量,且社会功能障碍和合并症发生率更高。ADHD患儿的身体成分、社会功能障碍和合并症之间存在临床相关性。

影响

  1. 亚阈值ADHD患儿和ADHD患儿的脂肪量水平高于正常儿童。2. 亚阈值ADHD患儿的社会功能障碍和合并症与ADHD患儿相似。3. 注意力不集中和焦虑/抑郁增加了ADHD患儿(全综合征/亚阈值)功能障碍的风险,而较高的去脂体重指数和骨骼肌与体脂比则降低了该风险。

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