Nilchian Firoozeh, Esrafili Mohammadreza, Hosseini Nafiseh
Department of Oral Public Health, Dental Materials Research Center, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Student Research Committee, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Dent Res J (Isfahan). 2024 Jul 12;21:38. eCollection 2024.
Clinical trials investigating the efficacy of oral health prevention materials have conventionally used indices to evaluate the amount of plaque on tooth surfaces. Various methods, including the use of probiotics, have been suggested to prevent oral disease. The present study was conducted to investigate the probiotic products available in Iranian pharmacies that are used for the prevention of dental disease.
In this double-blind randomized clinical trial, 40 students of medicine and pharmacy were randomly allocated into two equal groups of intervention and control using random allocation software. The intervention group used a probiotic pill containing M18 and K12 bacteria every night before going to bed. The control group used a mouth freshener tablet with the same flavor as the probiotic tablet every night before going to bed. The mean number of bacteria in both the groups was calculated before and after using probiotic pills. The data were staticali analyzed by descriptive statistics (central tendency and dispersion) and inferential statistics (paired -test and independent -test) and Kolmogorov-Smironove tests (<0.05).
The plaque index values at the beginning of the study showed no statistical differences between the intervention and control groups ( = 0.85). The plaque index values in the intervention group before and after the intervention were 0.41 and 0.75, respectively, which showed a statistically significant difference ( < 0.05). The plaque index values in the control group before and after the intervention were 0.42 and 0.42, respectively, which indicated no statistically significant difference ( > 0.05).
The mean plaque index in the group using probiotic tablets was significantly increased compared to those of the control group. However, further studies are suggested to evaluate these products.
研究口腔健康预防材料功效的临床试验通常使用指数来评估牙齿表面的菌斑量。已经提出了包括使用益生菌在内的各种方法来预防口腔疾病。本研究旨在调查伊朗药店中用于预防牙科疾病的益生菌产品。
在这项双盲随机临床试验中，使用随机分配软件将40名医科和药学专业的学生随机分为两组，每组人数相等，分别为干预组和对照组。干预组每晚睡前服用一片含有M18和K12细菌的益生菌药丸。对照组每晚睡前服用一片与益生菌片味道相同的口香片。在服用益生菌药丸前后计算两组中的细菌平均数。数据通过描述性统计（集中趋势和离散度）和推断性统计（配对检验和独立检验）以及Kolmogorov-Smironove检验（<0.05）进行统计学分析。
研究开始时的菌斑指数值在干预组和对照组之间没有统计学差异（=0.85）。干预组干预前后的菌斑指数值分别为0.41和0.75，显示出统计学上的显著差异（<0.05）。对照组干预前后的菌斑指数值分别为0.42和0.42，表明没有统计学上的显著差异（>0.05）。
与对照组相比，使用益生菌片的组的平均菌斑指数显著增加。然而，建议进一步研究以评估这些产品。
