No Eun-Gyu, Blank Heidi M, Polymenis Michael
Department of Biochemistry and Biophysics, Texas A&M University TX, 77843 U.S.A.
Microb Cell. 2024 Aug 20;11:321-327. doi: 10.15698/mic2024.08.835. eCollection 2024.
Proteins are the principal macromolecular constituent of proliferating cells, and protein synthesis is viewed as a primary metric of cell growth. While there are celebrated examples of proteins whose levels are periodic in the cell cycle (e.g., cyclins), the concentration of most proteins was not thought to change in the cell cycle, but some recent results challenge this notion. The 'bulk' protein is the focus of this article, specifically the rate of its synthesis, in the budding yeast .
蛋白质是增殖细胞的主要大分子成分，蛋白质合成被视为细胞生长的主要指标。虽然有一些著名的例子表明某些蛋白质的水平在细胞周期中呈周期性变化（例如细胞周期蛋白），但大多数蛋白质的浓度在细胞周期中被认为不会改变，不过最近的一些结果对这一观点提出了挑战。本文关注的是“总体”蛋白质，特别是其在芽殖酵母中的合成速率。
