Kim Siyoung, Cho Seong-Yong, Yoon Seongyong, Kim Daehwan, Park Hyun Woo, Kang Jisoo, Huh Sung Woo
Department of Occupational and Environmental Medicine, Soonchunhyang University Gumi Hospital, Gumi, Korea.
Ann Occup Environ Med. 2024 Aug 6;36:e20. doi: 10.35371/aoem.2024.36.e20. eCollection 2024.
Benzophenone-3 is a type of ketone with 2 benzene rings attached to a carbonyl group (C=O) and one benzene ring attached to a hydroxyl group (-OH). As an endocrine-disrupting chemical, benzophenone-3 is known to be associated with reproductive, developmental, thyroid, and endocrine toxicities. Benzophenone-3 is commonly used in hair products, cosmetics, and ultraviolet (UV) filters because of its characteristic property to absorb UV light. This study aims to investigate the association between the use of hair products and urine benzophenone-3 using the data from the Korean National Environmental Health Survey (KoNEHS) cycle 4 (2018-2020), which represents the Korean population.
Using the KoNEHS cycle 4 survey, the data of 3,796 adults aged ≥ 19 years were analyzed. Based on the 75th percentile concentration of urine benzophenone-3, the participants were divided into the low- and high-concentration groups. Chi-square test was conducted to analyze the association of urine benzophenone-3 with distribution of general characteristics, use of personal care products, consumption of marine foods, and use of plastic products as the variable. Logistic regression analysis was conducted to calculate odds ratios (ORs) for the high-concentration group of urine benzophenone-3 based on the use of hair products.
Women with < 6 times or ≥ 6 times of hair product usage had significantly higher adjusted ORs compared to those who did not use hair products. The calculated ORs were 1.24 (95% confidence interval [CI]: 1.12-1.38) for women with < 6 times of usage and 1.54 (95% CI: 1.33-1.79) for women with ≥ 6 times of usage.
This study revealed the association between the use of hair products and the concentration of urine benzophenone-3 in the general Korean population.
二苯甲酮-3是一种酮类物质，有两个苯环连接在羰基（C=O）上，一个苯环连接在羟基（-OH）上。作为一种内分泌干扰化学物质，二苯甲酮-3已知与生殖、发育、甲状腺和内分泌毒性有关。由于其吸收紫外线的特性，二苯甲酮-3常用于护发产品、化妆品和紫外线（UV）过滤器中。本研究旨在利用韩国国家环境健康调查（KoNEHS）第4轮（2018 - 2020年）的数据，该数据代表韩国人群，来调查护发产品使用与尿液中二苯甲酮-3之间的关联。
使用KoNEHS第4轮调查数据，对3796名年龄≥19岁的成年人的数据进行分析。根据尿液中二苯甲酮-3的第75百分位数浓度，将参与者分为低浓度组和高浓度组。进行卡方检验以分析尿液中二苯甲酮-3与一般特征分布、个人护理产品使用、海产品消费以及塑料制品使用等变量之间的关联。进行逻辑回归分析以计算基于护发产品使用情况的尿液中二苯甲酮-3高浓度组的比值比（OR）。
与未使用护发产品的女性相比，使用护发产品次数<6次或≥6次的女性调整后的OR显著更高。使用次数<6次的女性计算出的OR为1.24（95%置信区间[CI]：1.12 - 1.38），使用次数≥6次的女性为1.54（95%CI：1.33 - 1.79）。
本研究揭示了韩国普通人群中护发产品使用与尿液中二苯甲酮-3浓度之间的关联。
