Park Minkyu, Kim Seyoung, Kim Yeji, Nam Do Jin, Ryoo Jae-Hong, Lim Sinye
1Department of Occupational and Environmental Medicine, Kyung Hee University Medical Center, Seoul, South Korea.
2Department of Occupational and Environmental Medicine, School of Medicine Kyung Hee University, Seoul, Korea.
Ann Occup Environ Med. 2019 Jan 28;31:2. doi: 10.1186/s40557-019-0283-y. eCollection 2019.
We aimed to find the exposure level of triclosan (TCS), a known endocrine disruptor, related to the use of personal care products using a nationally representative data of the general population in Korea.
This study included data of 6288 adults aged 19 years and older (2692 men, 3596 women), based on the Second Korean National Environmental Health Survey (KoNEHS 2012-2014). The data were divided according to gender. The frequency and proportion of each variable were determined by dividing participants into two groups based on the top 75th percentile concentration of urinary TCS (male: 1.096 μg/g creatinine, female: 1.329 μg/g creatinine). Odds ratios (ORs) were calculated using logistic regression analysis for the high TCS exposure and low TCS exposure groups.
Overall, the proportion of participants using personal care products was higher in women than in men. There was a significantly higher proportion of participants in the high TCS exposure group with younger age, higher education and income levels and with more frequent use of fragrance products, hair care products, body cleansers, cosmetics, and antimicrobial agents. In both men and women, ORs tended to increase with increased frequency of use of hair care products, body cleansers, and cosmetics before and after adjustment.
Our findings demonstrate that as the frequency of use of personal care products increases, urine TCS concentration increases. Because TCS is a well-known endocrine disruptor, further studies are needed and explore other health effects with exposure to TCS in general population in Korea.
我们旨在利用韩国普通人群具有全国代表性的数据，找出与个人护理产品使用相关的已知内分泌干扰物三氯生（TCS）的暴露水平。
本研究纳入了基于第二次韩国国家环境卫生调查（2012 - 2014年韩国国家环境卫生调查）的6288名19岁及以上成年人的数据（2692名男性，3596名女性）。数据按性别划分。根据尿TCS浓度的第75百分位数将参与者分为两组，确定每个变量的频率和比例（男性：1.096μg/g肌酐，女性：1.329μg/g肌酐）。使用逻辑回归分析计算高TCS暴露组和低TCS暴露组的优势比（OR）。
总体而言，使用个人护理产品的参与者比例女性高于男性。高TCS暴露组中年龄较小、教育程度和收入水平较高且更频繁使用香水产品、护发产品、沐浴露、化妆品和抗菌剂的参与者比例显著更高。在男性和女性中，调整前后，OR均倾向于随着护发产品、沐浴露和化妆品使用频率的增加而增加。
我们的研究结果表明，随着个人护理产品使用频率的增加，尿TCS浓度升高。由于TCS是一种知名的内分泌干扰物，因此需要进一步研究，并探索韩国普通人群接触TCS的其他健康影响。
