Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India.
Center for Antimicrobial Resistance and Education, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India.
Am J Trop Med Hyg. 2024 Aug 27;111(5):1066-1069. doi: 10.4269/ajtmh.24-0193. Print 2024 Nov 6.
Gastroenteritis is the frequent clinical manifestation of infection by Campylobacter spp., whereas invasive infections such as bacteremia are less commonly reported. We report 12 cases of Campylobacter bacteremia from a tertiary-care hospital in India and describe their relatively unique characteristics compared with the previously published reports. These cases were detected after the introduction of new blood culture media. The most common symptoms were fever (eight cases, 67%), abdominal pain (six cases, 50%), and vomiting (four cases, 33%), whereas only two cases (17%) had diarrhea. Chronic liver disease was the common underlying condition affecting eight patients (75%). The median Child-Pugh and Model for End-Stage Liver Disease scores were 9 (interquartile range: 7-9.5) and 20 (interquartile range: 15-23) respectively. Campylobacter jejuni was isolated in six patients (50%), two of whom had preceding diarrhea and one patient who had culture evidence of C. jejuni in ascitic fluid. The in-hospital mortality was 8%, but this was due to subsequent Escherichia coli sepsis.
肠胃炎是弯曲杆菌属感染的常见临床症状，而菌血症等侵袭性感染则较少见。我们报告了来自印度一家三级保健医院的 12 例弯曲杆菌菌血症，并描述了与先前发表的报告相比，这些病例具有相对独特的特征。这些病例是在引入新的血培养介质后发现的。最常见的症状是发热（8 例，67%）、腹痛（6 例，50%）和呕吐（4 例，33%），而仅有 2 例（17%）出现腹泻。慢性肝病是影响 8 名患者（75%）的常见潜在疾病。Child-Pugh 和终末期肝病模型评分中位数分别为 9（四分位间距：7-9.5）和 20（四分位间距：15-23）。6 名患者（50%）分离出空肠弯曲菌，其中 2 例患者此前有腹泻，1 例患者腹水有空肠弯曲菌培养证据。住院死亡率为 8%，但这是由于随后发生的大肠杆菌败血症所致。
