Clinica Medica "A. Murri", Department of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), University of Bari "Aldo Moro", Piazza Giulio Cesare 11, Bari 70124, Italy.
Clinica Medica "A. Murri", Department of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), University of Bari "Aldo Moro", Piazza Giulio Cesare 11, Bari 70124, Italy.
Eur J Intern Med. 2024 Nov;129:111-120. doi: 10.1016/j.ejim.2024.08.014. Epub 2024 Aug 26.
Ramadan Intermittent fasting (RIF) exerts beneficial metabolic effects and improves gastrointestinal motility. However, a comparison between RIF and the traditional 16-hours intermittent fasting (16IF), a strategy for weight loss, is lacking.
A total of 34 subjects (median age 32.5 years, range 18-63 years; median BMI 24.5 Kg m², range 18.6-37.6 Kg m²) were assigned to RIF (N = 18) or 16IF (N = 16) for 30 days. We measured variations in anthropometric measures (BMI, waist, and abdominal circumference), serum insulin, glucose, cortisol, non-esterified fatty acid (NEFA), body fat composition (bioelectrical impedance analysis), and the ultrasonographic measurements of liver steatosis (Hepatorenal index, HRI) and thickness of subcutaneous (SAT) and visceral (VAT) fats.
At baseline, BMI, rates of liver steatosis and distribution of normal weight, overweight, and obese subjects were comparable between the two groups. Body weight significantly decreased at the end of fasting in both RIF (-4.2 % vs baseline, P = 0.002) and 16IF (-2.1 % vs baseline, P = 0.002). Waist and abdominal circumferences significantly decreased only in RIF as well as the amount of body fat. In subjects with liver steatosis, SAT and VAT significantly decreased following RIF, but not 16h-IF, as well as the ultrasonographic HRI.
Both 16IF and RIF are able, during 1-month, to reduce body weight. However, RIF but not 16IF also generates marked beneficial effects in terms of reduced subcutaneous fat and liver steatosis. Further studies urge to verify the effects of different models of IF in weight-cycling and long-term management of obesity and related dysmetabolic conditions, such as ectopic fat over-storage.
斋月间歇性禁食（RIF）对代谢有益，并能改善胃肠道动力。然而，RIF 与传统的 16 小时间歇性禁食（16IF）（一种减肥策略）之间的比较尚缺乏。
共有 34 名受试者（中位数年龄 32.5 岁，范围 18-63 岁；中位数 BMI 24.5kg/m²，范围 18.6-37.6kg/m²）被分配到 RIF（N=18）或 16IF（N=16）中进行 30 天的禁食。我们测量了人体测量学指标（BMI、腰围和腹围）、血清胰岛素、葡萄糖、皮质醇、非酯化脂肪酸（NEFA）、体脂肪成分（生物电阻抗分析）以及肝脂肪变性的超声测量值（肝肾指数，HRI）和皮下（SAT）和内脏（VAT）脂肪的厚度。
在基线时，两组的 BMI、肝脂肪变性的发生率以及正常体重、超重和肥胖受试者的分布情况均相似。在两种禁食方式下，体重在禁食结束时均显著下降（RIF：-4.2%，基线，P=0.002；16IF：-2.1%，基线，P=0.002）。腰围和腹围仅在 RIF 中显著下降，以及体脂肪量。在有肝脂肪变性的受试者中，SAT 和 VAT 在 RIF 后显著下降，但 16h-IF 没有，超声 HRI 也下降了。
在 1 个月的时间内，16IF 和 RIF 都能减轻体重。然而，RIF 除了能减轻体重外，还能显著降低皮下脂肪和肝脂肪变性。进一步的研究需要验证不同 IF 模式在体重循环和肥胖及其相关代谢紊乱的长期管理中的效果，例如异位脂肪储存过多。
