Gómez Jorge A, Cintra Otavio, Berzanskis Arnas, Pacheco Salma, Jaswantlal Henny, Hasnaoui Abdelkader El, van Oorschot Desirée A M, Guzman-Holst Adriana
Value Evidence & Outcomes, Vaccines, Emerging Markets, GSK, Buenos Aires 1429, Argentina.
Medical Affairs, Vaccines, Emerging Markets, GSK, Sao Paulo 04001-083, Brazil.
Infect Dis Rep. 2024 Aug 15;16(4):750-762. doi: 10.3390/idr16040057.
Respiratory syncytial virus (RSV) is an important cause of severe respiratory disease in older adults. Understanding the disease burden is crucial for guiding vaccination policy and raising disease awareness. We estimated the burden of RSV hospitalizations and deaths in adults in five middle-income countries: Argentina, Brazil, Chile, Mexico, and Malaysia. Hospital discharge and death statistics due to any respiratory disease (ICD-10 codes: J00-99) from 2010 to 2022 were obtained. The RSV attributable burden on hospitalizations and deaths by age group was determined for 2019 using previously published estimates. Latin American countries showed distinct annual peaks in respiratory-related hospitalizations and deaths during winter months that were absent in Malaysia. Among ≥20-year-olds in 2019, there were 14,604 RSV-attributable hospitalizations nationally in Argentina, 44,323 in Brazil, 4529 in Chile, 7416 in Malaysia, and 8651 in Mexico, and 60-74% in ≥65-year-olds. There were also 3518 RSV-attributable deaths in Argentina, 9115 in Brazil, 801 in Chile, 704 in Malaysia, and 3806 in Mexico 79-88% in ≥65-year-olds. Incidences of RSV-attributable hospitalizations in ≥75-year-olds ranged between 256.3 and 294.3 per 100,000 population, and deaths between 33.6 and 112.9 per 100,000 population. RSV is associated with a substantial disease burden beyond pediatric age groups, and preventive vaccines could have a major impact on this burden, especially in older adults.
呼吸道合胞病毒（RSV）是导致老年人严重呼吸道疾病的重要原因。了解疾病负担对于指导疫苗接种政策和提高疾病认知至关重要。我们估算了五个中等收入国家（阿根廷、巴西、智利、墨西哥和马来西亚）成年人中RSV住院和死亡的负担。获取了2010年至2022年因任何呼吸道疾病（国际疾病分类第十版编码：J00 - 99）导致的医院出院和死亡统计数据。利用先前发表的估算方法确定了2019年各年龄组RSV导致的住院和死亡负担。拉丁美洲国家在冬季出现了与呼吸道相关的住院和死亡的明显年度高峰，而马来西亚没有。在2019年年龄≥20岁的人群中，阿根廷全国有14,604例RSV导致的住院病例，巴西有44,323例，智利有4529例，马来西亚有7416例，墨西哥有8651例，65岁及以上人群占60 - 74%。阿根廷还有3518例RSV导致的死亡病例，巴西有9115例，智利有801例，马来西亚有704例，墨西哥有3806例，65岁及以上人群占79 - 88%。75岁及以上人群中RSV导致的住院发病率在每10万人256.3至294.3例之间，死亡率在每10万人33.6至112.9例之间。RSV在儿童年龄组之外还与相当大的疾病负担相关，预防性疫苗可能会对这一负担产生重大影响，尤其是对老年人。
