Department of The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, China.
Department of Obstetrics and Gynecology, Affiliated Hangzhou First People's Hospital, Xihu University, Hangzhou, 310006, Zhejiang, P.R. China.
Funct Integr Genomics. 2024 Aug 28;24(5):144. doi: 10.1007/s10142-024-01432-w.
Ovarian cancer is a malignant tumor of ovary. It has the characteristics of difficult early diagnosis, poor late curative effect and high recurrence rate. It is the biggest disease that seriously threatens women's health. Single cell sequencing technology refers to sequencing the genetic information carried by it at the single cell level to obtain the gene sequence, transcript, protein and epigenetic expression profile information of a certain cell type and conduct integrated analysis. It has unique advantages in the study of tumor occurrence and evolution, and can provide new methods for the study of ovarian cancer. This paper reviews the single cell sequencing technology and its application in ovarian cancer.
卵巢癌是卵巢的一种恶性肿瘤。它具有早期诊断困难、晚期疗效差和复发率高的特点。是严重威胁妇女健康的最大疾病。单细胞测序技术是指在单细胞水平上对其携带的遗传信息进行测序，获得特定细胞类型的基因序列、转录本、蛋白质和表观遗传表达谱信息，并进行综合分析。它在肿瘤发生和演变的研究中具有独特的优势，可以为卵巢癌的研究提供新的方法。本文综述了单细胞测序技术及其在卵巢癌中的应用。
