Hori Taiki, Aihara Ken-Ichi, Watanabe Takeshi, Inaba Kaori, Inaba Keisuke, Kaneko Yousuke, Kawata Saki, Kawahito Keisuke, Kita Hiroki, Shimizu Kazuma, Hosoki Minae, Mori Kensuke, Kageji Teruyoshi, Uraoka Hideyuki, Nakamura Shingen
Department of Internal Medicine, Tokushima Prefectural Kaifu Hospital, 266 Sugitani, Nakamura, Mugi-cho, Kaifu-gun, Tokushima 775-0006, Japan.
Department of Hematology, Endocrinology and Metabolism, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.
J Clin Med. 2024 Aug 18;13(16):4866. doi: 10.3390/jcm13164866.
: The respiratory adjusted shock index (RASI) is a risk score whose usefulness in patients with sepsis and trauma has previously been reported. However, its relevance in elderly emergency patients with medical diseases is yet to be clarified. This study assessed the usefulness of the RASI, which can be evaluated without requiring special equipment, to provide objective and rapid emergency responses. : In this retrospective study, we recruited patients with medical diseases, aged 65 years or older, who were transported to the emergency room from Tokushima Prefectural Kaifu Hospital and underwent arterial blood gas testing from 1 January 2022 to 31 December 2023. We investigated the association of the RASI with other indices, including the lactate level, National Early Warning Score 2 (NEWS2), Shock Index (SI), Sequential Organ Failure Assessment (SOFA) score, quick SOFA (qSOFA) score, and systemic inflammatory response syndrome (SIRS). In this study, we included 260 patients (mean age, 86 years), of whom 234 were admitted to the hospital; 27 and 49 patients died within 7 and 30 days of admission, respectively. The RASI was positively correlated with the lactate level, NEWS2, SI, and increase in the SOFA score ( < 0.001). The RASI was higher in patients with a SIRS or qSOFA score ≥ 2 than in those without ( < 0.001). It predicted death within 7 and 30 days of admission with an area under the curve (AUC) of 0.80 (95% confidence interval [CI]: 0.73-0.87), sensitivity of 96.3%, and specificity of 53.6% when the cutoff value was set to 1.58 and with an AUC of 0.73 (95% CI: 0.66-0.81), sensitivity of 69.4%, and specificity of 70.6% when the cutoff value was set to 1.83, respectively. : The RASI is a simple indicator that can be used for predicting in-hospital outcomes in elderly emergency patients with medical diseases. Larger prospective studies based on this study are needed.
呼吸调整休克指数(RASI)是一种风险评分,此前已有报道称其在脓毒症和创伤患者中具有实用性。然而,其在患有内科疾病的老年急诊患者中的相关性尚待阐明。本研究评估了无需特殊设备即可评估的RASI在提供客观快速的急诊反应方面的实用性。
在这项回顾性研究中,我们招募了65岁及以上患有内科疾病、从德岛县海府医院转运至急诊室且在2022年1月1日至2023年12月31日期间接受动脉血气检测的患者。我们调查了RASI与其他指标的相关性,包括乳酸水平、国家早期预警评分2(NEWS2)、休克指数(SI)、序贯器官衰竭评估(SOFA)评分、快速SOFA(qSOFA)评分和全身炎症反应综合征(SIRS)。在本研究中,我们纳入了260例患者(平均年龄86岁),其中234例入院;分别有27例和49例患者在入院7天和30天内死亡。RASI与乳酸水平、NEWS2、SI以及SOFA评分的增加呈正相关(<0.001)。SIRS或qSOFA评分≥2的患者的RASI高于无此情况的患者(<0.001)。当临界值设定为1.58时,其预测入院7天和30天内死亡的曲线下面积(AUC)为0.80(95%置信区间[CI]:0.73 - 0.87),敏感性为96.3%,特异性为53.6%;当临界值设定为1.83时,AUC为0.73(95%CI:0.66 - 0.81),敏感性为69.4%,特异性为70.6%。
RASI是一种简单的指标,可用于预测患有内科疾病的老年急诊患者的院内结局。需要基于本研究开展更大规模的前瞻性研究。