T细胞以及可能的B细胞源自慢性粒细胞白血病中的恶性克隆。
T cells and probably B cells arise from the malignant clone in chronic myelogenous leukemia.
作者信息
Fauser A A, Kanz L, Bross K J, Löhr G W
出版信息
J Clin Invest. 1985 Mar;75(3):1080-2. doi: 10.1172/JCI111771.
Abstract
Bone marrow cells from a patient with Ph' positive chronic myelogenous leukemia in chronic phase were cultured for multilineage hematopoietic colonies (CFU-GEMMT), erythroid bursts, and granulocytic colonies. With CFU-GEMMT colonies, T lymphocytes were identified by reaction with monoclonal antibodies Leu-5 and OKT-3; B cells were identified by reaction with B1. All CFU-GEMMT colonies examined contained the Ph' chromosome. Recloned secondary colonies of T cells reacted with Leu-5 and OKT-3 and were Ph' positive. This demonstrates that Ph' positive T lymphocytes were generated from the pluripotential stem cell of this patient. The presence of B cells in the mixed colonies indicates that these may also be derived from the neoplastic clone.
摘要
对一名处于慢性期的Ph'阳性慢性粒细胞白血病患者的骨髓细胞进行培养，以形成多系造血集落（CFU-GEMMT）、红系爆式集落和粒系集落。对于CFU-GEMMT集落，通过与单克隆抗体Leu-5和OKT-3反应鉴定T淋巴细胞；通过与B1反应鉴定B细胞。所有检测的CFU-GEMMT集落都含有Ph'染色体。再次克隆的T细胞次级集落与Leu-5和OKT-3反应且Ph'呈阳性。这表明Ph'阳性T淋巴细胞是由该患者的多能干细胞产生的。混合集落中B细胞的存在表明它们也可能来源于肿瘤克隆。
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1
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3
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Blood. 1981 Aug;58(2):402-5.
4
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J Cell Physiol Suppl. 1982;1:79-85. doi: 10.1002/jcp.1041130413.
5
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6
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8
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9
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