Department of Materials Science and Engineering, University of Ioannina, 45110 Ioannina, Greece.
Nanomedicine and Nanobiotechnology Research Group, University of Ioannina, 45110 Ioannina, Greece.
Molecules. 2024 Aug 22;29(16):3967. doi: 10.3390/molecules29163967.
Porous carbon materials from food waste have gained growing interest worldwide for multiple applications due to their natural abundance and the sustainability of the raw materials and the cost-effective synthetic processing. Herein, orange waste-derived porous carbon (OWPC) was developed through a freeze-drying method to prevent the demolition of the original biomass structure and then was pyrolyzed to create a large number of micro, meso and macro pores. The novelty of this work lies in the fact of using the macro-channels of the orange waste in order to create a macroporous network via the freeze-drying method which remains after the pyrolysis steps and creates space for the development of different types of porous in the micro and meso scale in a controlled way. The results showed the successful preparation of a porous carbon material with a high specific surface area of 644 m g without any physical or chemical activation. The material's cytocompatibility was also investigated against a fibroblast cell line (NIH/3T3 cells). OWPC triggered a mild intracellular reactive oxygen species production without initiating apoptosis or severely affecting cell proliferation and survival. The combination of their physicochemical characteristics and high cytocompatibility renders them promising materials for further use in biomedical and pharmaceutical applications.
由于其天然丰度以及原材料的可持续性和具有成本效益的合成处理，源自食品废弃物的多孔碳材料在多个应用领域引起了全球越来越多的关注。本文通过冷冻干燥法制备了源自橙废料的多孔碳（OWPC），以防止原始生物质结构的破坏，然后对其进行热解，以在微、介观和宏观尺度上产生大量的微孔、介孔和大孔。这项工作的新颖之处在于利用橙废料的大通道，通过冷冻干燥法在热解步骤后留下大孔网络，为在微介观尺度上开发不同类型的多孔提供空间，并以可控的方式进行。结果表明，成功地制备了一种具有 644 m²/g 高比表面积的多孔碳材料，无需任何物理或化学活化。还研究了该材料对成纤维细胞系（NIH/3T3 细胞）的细胞相容性。OWPC 引发了温和的细胞内活性氧物质产生，而不会引发细胞凋亡或严重影响细胞增殖和存活。它们的物理化学特性和高细胞相容性的结合使它们成为在生物医学和制药应用中进一步使用的有前途的材料。
