Faculty of Medicine and Health Science, UCSI University, Kuala Lumpur 56000, Malaysia.
Faculty of Medicine and Allied Medical Sciences, Isra University, New Hala-Mirpur Khas Rd Link, Hyderabad 71000, Pakistan.
Nutrients. 2024 Aug 20;16(16):2779. doi: 10.3390/nu16162779.
Gastroesophageal reflux disease (GERD) is a prevalent chronic condition affecting the well-being of both adults and children in general medical practice. Research on the effects of fermented soybean (SB) supplementation in managing GERD is relatively new, with limited studies available. The existing research often lacks sufficient dosing regimens and study durations to differentiate between transient placebo effects and sustained benefits. In this study, the beneficial effects of FSB supplementation were investigated in 110 voluntary participants (NCT06524271). The participants were required to take 1 g of FSB supplement once daily for 12 weeks. GERD symptoms were evaluated using the Reflux Disease Questionnaire (RDQ), while inflammatory markers, including interleukin-4 (IL-4), interleukin-6 (IL-6), and interleukin-8 (IL-8), were measured to assess inflammation. The Quality of Life in Reflux and Dyspepsia (QOLRAD) questionnaire was used to evaluate participants' quality of life. The results indicated that FSB supplementation significantly ( < 0.05) alleviated heartburn and regurgitation symptoms and reduced levels of IL-4, IL-6, and IL-8, indicating a notable anti-inflammatory effect. Additionally, significant ( < 0.05) improvements were observed in QOLRAD scores, particularly in vitality, emotional distress, and physical/social functioning. Collectively, our findings support the use of FSB as an adjuvant approach in managing GERD, with notable improvements in patients' quality of life.
胃食管反流病（GERD）是一种常见的慢性疾病，普遍影响着普通医疗实践中成人和儿童的健康。关于发酵大豆（SB）补充剂在管理 GERD 方面的影响的研究相对较新，可用的研究有限。现有的研究往往缺乏足够的剂量方案和研究持续时间，难以区分短暂的安慰剂效应和持续的益处。在这项研究中，110 名自愿参与者（NCT06524271）接受了 FSB 补充剂的有益效果的调查。参与者需要每天服用 1 克 FSB 补充剂，持续 12 周。使用反流疾病问卷（RDQ）评估 GERD 症状，同时测量炎症标志物，包括白细胞介素-4（IL-4）、白细胞介素-6（IL-6）和白细胞介素-8（IL-8），以评估炎症。使用反流和消化不良生活质量问卷（QOLRAD）评估参与者的生活质量。结果表明，FSB 补充剂显著（<0.05）缓解了烧心和反流症状，并降低了 IL-4、IL-6 和 IL-8 的水平，表明具有显著的抗炎作用。此外，QOLRAD 评分也有显著（<0.05）改善，特别是在活力、情绪困扰和身体/社会功能方面。总的来说，我们的发现支持使用 FSB 作为管理 GERD 的辅助方法，患者的生活质量有显著改善。
