Department of Cardiac Surgery, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), 570311 Haikou, Hainan, China.
Department of Cardiothoracic Surgery, Ezhou Central Hospital, 436000 Ezhou, Hubei, China.
Front Biosci (Landmark Ed). 2024 Aug 19;29(8):286. doi: 10.31083/j.fbl2908286.
Being one of the pivotal adipocytokines, adiponectin binds to various receptors and exerts diverse biological functions, encompassing anti-fibrosis, anti-atherosclerosis, anti-ischemia-reperfusion, regulation of inflammation, and modulation of glucose and lipid metabolism. Alterations in adiponectin levels are observed in patients afflicted with diverse cardiovascular diseases. This paper comprehensively reviews the impact of adiponectin on the pathogenesis and progression of cardiovascular diseases, elucidating the underlying cellular and molecular mechanisms along with the associated cell signaling pathways. Furthermore, it deliberates on the diagnostic and predictive efficacy of adiponectin as a protein marker for cardiovascular diseases. Additionally, it outlines methods for manipulating adiponectin levels . A thorough understanding of these interconnections can potentially inform clinical strategies for the prevention and management of cardiovascular diseases.
作为关键的脂肪因子之一，脂联素与各种受体结合，发挥多种生物学功能，包括抗纤维化、抗动脉粥样硬化、抗缺血再灌注、调节炎症以及调节葡萄糖和脂质代谢。在患有各种心血管疾病的患者中，脂联素水平发生改变。本文全面综述了脂联素对心血管疾病发病机制和进展的影响，阐明了相关的细胞和分子机制以及相关的细胞信号通路。此外，还讨论了脂联素作为心血管疾病蛋白标志物的诊断和预测效能。还概述了调节脂联素水平的方法。深入了解这些相互关系可能为心血管疾病的预防和管理提供临床策略。
