Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China.
The Key Laboratory of Molecular Biology of Infectious Diseases Designated By the Chinese Ministry of Education, Chongqing Medical University, Chongqing, 400016, China.
Funct Integr Genomics. 2024 Aug 29;24(5):146. doi: 10.1007/s10142-024-01427-7.
Hepatocellular carcinoma (HCC) is a major fatal cancer that is known for its high recurrence and metastasis. An increasing number of studies have shown that the tumor microenvironment is closely related to the metastasis and invasion of HCC. The HCC microenvironment is a complex integrated system composed of cellular components, the extracellular matrix (ECM), and signaling molecules such as chemokines, growth factors, and cytokines, which are generally regarded as crucial molecules that regulate a series of important processes, such as the migration and invasion of HCC cells. Considering the crucial role of signaling molecules, this review aims to elucidate the regulatory effects of chemokines, growth factors, and cytokines on HCC cells in their microenvironment to provide important references for clarifying the development of HCC and exploring effective therapeutic targets.
肝细胞癌（HCC）是一种主要的致命癌症，其复发和转移率很高。越来越多的研究表明，肿瘤微环境与 HCC 的转移和侵袭密切相关。HCC 微环境是一个由细胞成分、细胞外基质（ECM）和趋化因子、生长因子和细胞因子等信号分子组成的复杂综合系统，通常被认为是调节 HCC 细胞迁移和侵袭等一系列重要过程的关键分子。鉴于信号分子的重要作用，本综述旨在阐明趋化因子、生长因子和细胞因子在 HCC 细胞微环境中的调节作用，为阐明 HCC 的发生发展和探索有效的治疗靶点提供重要参考。
