Department of Neurology, Suining Central Hospital, Suining, China.
Department of Emergency, Suining Central Hospital, Suining, China.
Front Immunol. 2024 Aug 19;15:1451742. doi: 10.3389/fimmu.2024.1451742. eCollection 2024.
Numerous studies have investigated the relationship between gut microbiota (GM) and multiple sclerosis(MS), highlighting the significant role of GM in MS. However, there is a lack of systematic Scientometric analyses published in this specific research area to provide an overall understanding of the current research status.
Perform a scientometric analysis on research conducted between 2010 and 2023 concerning the link between GM and MS using quantitative and visual analysis software (CiteSpace and VOSviewer.).
From January 1, 2010, and December 31, 2023, a total of 1019 records about GM and MS were retrieved. The number of publications exhibited a consistent upward trend annually. The United States led in publications, showed the strongest level of collaboration among countries. The University of California, San Francisco stands as the top institution in terms of output, and the most prolific and cited authors were Lloyd H. Kasper and Javier Ochoa-Reparaz from the USA. The research in this field primarily centers on investigating the alterations and associations of GM in MS or EAE, the molecular immunological mechanisms, and the potential of GM-based interventions to provide beneficial effects in MS or EAE. The Keywords co-occurrence network reveals five primary research directions in this field. The most frequently occurring keywords are inflammation, probiotics, diet, dysbiosis, and tryptophan. In recent years, neurodegeneration and neuropsychiatric disorders have been prominent, indicating that the investigation of the mechanisms and practical applications of GM in MS has emerged as a current research focus. Moreover, GM research is progressively extending into the realm of neurodegenerative and psychiatric diseases, potentially becoming future research hotspots.
This study revealed a data-driven systematic comprehension of research in the field of GM in MS over the past 13 years, highlighted noteworthy research within the field, provided us with a clear understanding of the current research status and future trends, providing a valuable reference for researchers venturing into this domain.
大量研究探讨了肠道微生物群（GM）与多发性硬化症（MS）之间的关系，突出了 GM 在 MS 中的重要作用。然而，在这一特定研究领域，缺乏系统的科学计量学分析，无法全面了解当前的研究现状。
使用定量和可视化分析软件（CiteSpace 和 VOSviewer）对 2010 年至 2023 年间 GM 与 MS 之间关联的研究进行科学计量学分析。
从 2010 年 1 月 1 日至 2023 年 12 月 31 日，共检索到 1019 篇关于 GM 和 MS 的记录。出版物数量呈逐年持续上升趋势。美国在出版物方面处于领先地位，各国之间的合作水平最强。在产出方面，加州大学旧金山分校位居榜首，最具影响力和引用量的作者是美国的 Lloyd H. Kasper 和 Javier Ochoa-Reparaz。该领域的研究主要集中在研究 MS 或 EAE 中 GM 的变化和关联、分子免疫学机制，以及 GM 干预在 MS 或 EAE 中提供有益效果的潜力。关键词共现网络揭示了该领域的五个主要研究方向。出现频率最高的关键词是炎症、益生菌、饮食、生态失调和色氨酸。近年来，神经退行性变和神经精神疾病成为突出问题，表明 GM 在 MS 中的机制和实际应用的研究已成为当前的研究重点。此外，GM 研究正在逐步扩展到神经退行性和精神疾病领域，可能成为未来的研究热点。
本研究揭示了过去 13 年中 GM 与 MS 领域研究的基于数据的系统理解，突出了该领域的重要研究，使我们清楚地了解了当前的研究现状和未来趋势，为涉足该领域的研究人员提供了有价值的参考。
