Wang Shuai, Tu Yan, Yu Hao, Li Zhen, Feng Jinqiu, Liu Shangfeng
Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital, Fudan University, 365 Beijing Road, Shanghai, 200001, People's Republic of China.
Department of Pediatrics, Shanghai Stomatological Hospital, Fudan University, Shanghai, 200001, People's Republic of China.
Odontology. 2025 Jan;113(1):42-60. doi: 10.1007/s10266-024-00987-1. Epub 2024 Sep 3.
The intricate and protracted process of dentin formation has been extensively explored, thanks to the significant advancements facilitated by the use of animal models and related techniques. Despite variations in their effectiveness, taking into account factors such as sensitivity, visibility, and reliability, these models or techniques are indispensable tools for investigating the complexities of dentin formation. This article focuses on the latest advances in animal models and related technologies, shedding light on the key molecular mechanisms that are essential in dentin formation. A deeper understanding of this phenomenon enables the careful selection of appropriate animal models, considering their suitability in unraveling the underlying molecular intricacies. These insights are crucial for the advancement of clinical drugs targeting dentin-related ailments and the development of comprehensive treatment strategies throughout the duration of the disease.
由于使用动物模型及相关技术带来了重大进展，牙本质形成这一复杂而漫长的过程已得到广泛研究。尽管这些模型或技术在敏感性、可视性和可靠性等方面存在效果差异，但它们都是研究牙本质形成复杂性不可或缺的工具。本文重点介绍动物模型和相关技术的最新进展，揭示牙本质形成中至关重要的关键分子机制。深入了解这一现象有助于谨慎选择合适的动物模型，考虑其在揭示潜在分子复杂性方面的适用性。这些见解对于开发针对牙本质相关疾病的临床药物以及制定贯穿疾病全程的综合治疗策略至关重要。
