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The Case for Restoring Organelles to Treat Ischemic Cardiomyopathy: Is DEPP1 an Attractive Target?

作者信息

Diwan Abhinav

机构信息

Departments of Medicine, Cell Biology and Physiology, Obstetrics and Gynecology, and Neurology; Center for Cardiovascular Research; and Hope Center for Neurologic Disorders, Washington University School of Medicine, St Louis, MO. John Cochran Veterans Affairs Medical Center, St Louis, MO.

出版信息

Circulation. 2024 Sep 3;150(10):787-790. doi: 10.1161/CIRCULATIONAHA.124.070750.

DOI:10.1161/CIRCULATIONAHA.124.070750
PMID:39226384
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11373883/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d2/11373883/e6a57aeb941b/nihms-2012192-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d2/11373883/e6a57aeb941b/nihms-2012192-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/15d2/11373883/e6a57aeb941b/nihms-2012192-f0001.jpg

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本文引用的文献

1
Induction of DEPP1 by HIF Mediates Multiple Hallmarks of Ischemic Cardiomyopathy.低氧诱导因子介导 DEPP1 的诱导作用,从而介导缺血性心肌病的多种特征。
Circulation. 2024 Sep 3;150(10):770-786. doi: 10.1161/CIRCULATIONAHA.123.066628. Epub 2024 Jun 17.
2
Role of lipids in interorganelle communication.脂质在细胞器间通讯中的作用。
Trends Cell Biol. 2025 Jan;35(1):46-58. doi: 10.1016/j.tcb.2024.04.008. Epub 2024 Jun 11.
3
Targeting hypoxia-inducible factors: therapeutic opportunities and challenges.靶向低氧诱导因子:治疗机会与挑战。
Nat Rev Drug Discov. 2024 Mar;23(3):175-200. doi: 10.1038/s41573-023-00848-6. Epub 2023 Dec 20.
4
Brown Adipose Tissue and BMP3b Decrease Injury in Cardiac Ischemia-Reperfusion.棕色脂肪组织和 BMP3b 减少心脏缺血再灌注损伤。
Circ Res. 2023 Aug 4;133(4):353-365. doi: 10.1161/CIRCRESAHA.122.322337. Epub 2023 Jul 18.
5
Myocardial Revascularization in Patients With Ischemic Cardiomyopathy: For Whom and How.缺血性心肌病患者的心肌血运重建:适合哪些患者以及如何进行。
J Am Heart Assoc. 2023 Mar 21;12(6):e026943. doi: 10.1161/JAHA.122.026943. Epub 2023 Mar 9.
6
The Goldilocks Oxygen Principle: not too little and not too much.金凤花氧气原则:不多不少。
Nat Cardiovasc Res. 2022 Dec;1(12):1101-1103. doi: 10.1038/s44161-022-00178-7. Epub 2022 Dec 12.
7
BNIP3L/NIX regulates both mitophagy and pexophagy.BNIP3L/NIX 调节线粒体自噬和过氧化物酶体自噬。
EMBO J. 2022 Dec 15;41(24):e111115. doi: 10.15252/embj.2022111115. Epub 2022 Oct 10.
8
HIF in the heart: development, metabolism, ischemia, and atherosclerosis.心脏中的低氧诱导因子:发育、代谢、缺血和动脉粥样硬化。
J Clin Invest. 2021 Sep 1;131(17). doi: 10.1172/JCI137557.
9
Genetic Screen for Cell Fitness in High or Low Oxygen Highlights Mitochondrial and Lipid Metabolism.高或低氧条件下细胞适应性的遗传筛选凸显了线粒体和脂代谢。
Cell. 2020 Apr 30;181(3):716-727.e11. doi: 10.1016/j.cell.2020.03.029. Epub 2020 Apr 6.
10
A Novel Biological Strategy for Myocardial Protection by Intracoronary Delivery of Mitochondria: Safety and Efficacy.冠状动脉内递送线粒体实现心肌保护的新型生物学策略:安全性与有效性
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