Domingues Neuza, Pires Joana, Milosevic Ira, Raimundo Nuno
Multidisciplinary Institute of Ageing, University of Coimbra, Coimbra, Portugal.
Multidisciplinary Institute of Ageing, University of Coimbra, Coimbra, Portugal; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Trends Cell Biol. 2025 Jan;35(1):46-58. doi: 10.1016/j.tcb.2024.04.008. Epub 2024 Jun 11.
Cell homeostasis and function rely on well-orchestrated communication between different organelles. This communication is ensured by signaling pathways and membrane contact sites between organelles. Many players involved in organelle crosstalk have been identified, predominantly proteins and ions. The role of lipids in interorganelle communication remains poorly understood. With the development and broader availability of methods to quantify lipids, as well as improved spatiotemporal resolution in detecting different lipid species, the contribution of lipids to organelle interactions starts to be evident. However, the specific roles of various lipid molecules in intracellular communication remain to be studied systematically. We summarize new insights in the interorganelle communication field from the perspective of organelles and discuss the roles played by lipids in these complex processes.
细胞内稳态和功能依赖于不同细胞器之间精心编排的通讯。这种通讯由细胞器之间的信号通路和膜接触位点来确保。许多参与细胞器串扰的分子已被确定，主要是蛋白质和离子。脂质在细胞器间通讯中的作用仍知之甚少。随着脂质定量方法的发展和更广泛的应用，以及检测不同脂质种类时时空分辨率的提高，脂质对细胞器相互作用的贡献开始变得明显。然而，各种脂质分子在细胞内通讯中的具体作用仍有待系统研究。我们从细胞器的角度总结了细胞器间通讯领域的新见解，并讨论了脂质在这些复杂过程中所起的作用。
