CIISA - Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.
AL4AnimalS - Associate Laboratory for Animal & Veterinary Sciences, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.
Future Microbiol. 2024;19(16):1407-1418. doi: 10.1080/17460913.2024.2393003. Epub 2024 Sep 4.
, particularly and , are responsible for many hospital-acquired infections. With their intrinsic antibiotic resistance and ability to form biofilms, enterococcal infections are already challenging to manage. However, when heterogenous populations are present, such as those exhibiting heteroresistance and persistence, the complexity of these infections increases exponentially not only due to their treatment but also due to their difficult diagnosis. In this study, we provide a summary of the current understanding of both heteroresistance and persistence in terms of mechanisms, diagnosis and treatment and subsequently review recent literature pertaining to these susceptibility types specifically in enterococci.
, 特别是 和, 是许多医院获得性感染的罪魁祸首。肠球菌具有固有抗生素耐药性和形成生物膜的能力，因此其感染的管理已经颇具挑战性。然而，当存在异质群体时，例如表现出异质耐药性和持久性的群体，这些感染的复杂性会呈指数级增加，不仅因为它们的治疗难度，还因为它们的诊断难度。在这项研究中，我们根据机制、诊断和治疗方面，对异质耐药性和持久性的现有认识进行了总结，随后还特别对肠球菌中这些耐药类型的相关文献进行了回顾。
