Leary J V, Kfir R, Sims J J, Fulbright D W
Mutat Res. 1979 Dec;68(4):301-5. doi: 10.1016/0165-1218(79)90162-9.
5 polyhalogenated hydrocarbon natural products isolated from the marine red alga Plocamium spp. were tested for mutagenicity in the Ames reversion assay. All 5 of the compounds induced revertants in Salmonella typhimurium strains TA100 and TA1535, indicating the mutational events involved base substitutions. One of the compounds, designated cross-conjugated ketone, was shown to be almost 200 times more effective as a mutagen than was ethyl methanesulfonate.
对从海洋红藻Plocamium spp.中分离出的5种多卤代烃天然产物进行了Ames回复突变试验以检测其致突变性。所有这5种化合物均在鼠伤寒沙门氏菌TA100和TA1535菌株中诱导出回复突变体，表明所涉及的突变事件为碱基置换。其中一种化合物，命名为交叉共轭酮，其作为诱变剂的效力比甲磺酸乙酯高出近200倍。
