黄曲霉毒素B1在巨大芽孢杆菌中的作用机制。

Mechanism of action of aflatoxin B1 in Bacillus megaterium.

作者信息

Tiwari R P, Dham C K, Bhalla T C, Saini S S, Vadehra D V

出版信息

Appl Environ Microbiol. 1985 Apr;49(4):904-7. doi: 10.1128/aem.49.4.904-907.1985.

DOI:10.1128/aem.49.4.904-907.1985

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC238467/

Abstract

Bacillus megaterium cells from various growth phases were equally susceptible to the lethal effects of aflatoxin B1. Known surfactants (EDTA and Tween-80) accentuated the effects of aflatoxin B1. Viability and inulin uptake in aflatoxin B1-exposed cells decreased considerably. The effect was concentration dependent. A straight-line relationship observed in the death curve indicated a single target for aflatoxin B1 action in B. megaterium. Leakage of intracellular constituents in B. megaterium was also concentration dependent, and this can be related to the extent of cell membrane damage.

摘要

处于不同生长阶段的巨大芽孢杆菌细胞对黄曲霉毒素B1的致死作用同样敏感。已知的表面活性剂（乙二胺四乙酸和吐温80）会增强黄曲霉毒素B1的作用。暴露于黄曲霉毒素B1的细胞的活力和菊粉摄取量显著下降。这种作用具有浓度依赖性。在死亡曲线上观察到的直线关系表明黄曲霉毒素B1在巨大芽孢杆菌中的作用有单一靶点。巨大芽孢杆菌细胞内成分的泄漏也具有浓度依赖性，这可能与细胞膜损伤程度有关。

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