腹泻和呕吐婴儿的肠道通透性变化及粪便中微生物的排泄情况。
Intestinal permeability changes and excretion of micro-organisms in stools of infants with diarrhoea and vomiting.
作者信息
Weaver L T, Chapman P D, Madeley C R, Laker M F, Nelson R
出版信息
Arch Dis Child. 1985 Apr;60(4):326-32. doi: 10.1136/adc.60.4.326.
Abstract
The relation between diarrhoea and vomiting, the excretion of stool micro-organisms, and the passive intestinal permeability in 20 infants living in a deprived urban area was studied prospectively from birth to age 6 months. Intestinal permeability was measured from the ratio of lactulose to mannitol recovered in the urine of infants receiving feeds containing both markers. Micro-organism excretion was found to occur in both the presence and absence of gastrointestinal symptoms, but a significantly higher mean intestinal permeability was recorded in those infants with symptoms and organisms in the stool than in those with neither. An increased intestinal permeability may be a sign of mucosal damage by intestinal micro-organisms.
摘要
对20名生活在贫困市区的婴儿从出生到6个月大进行了前瞻性研究，以探讨腹泻与呕吐的关系、粪便微生物的排泄以及被动肠通透性。通过测定摄入含有两种标记物的喂养的婴儿尿液中回收的乳果糖与甘露醇的比例来测量肠通透性。发现无论有无胃肠道症状都会出现微生物排泄，但粪便中有症状和微生物的婴儿的平均肠通透性明显高于既无症状也无微生物的婴儿。肠通透性增加可能是肠道微生物对粘膜造成损伤的一个迹象。
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