Weaver L T, Laker M F, Nelson R
Arch Dis Child. 1984 Mar;59(3):236-41. doi: 10.1136/adc.59.3.236.
Passive intestinal permeability in 33 newborn babies was studied using feeds containing lactulose and mannitol. Each marker is thought to pass across the gut wall by a different route; lactulose by a paracellular and mannitol by a transcellular pathway. Neither is metabolised and both are wholly and solely excreted by the kidney; urinary recovery is a measure of the intestinal uptake. Babies born before 34 weeks' gestation exhibited a higher intestinal permeability to lactulose than more mature babies, and all preterm babies showed an appreciable decline in lactulose absorption during the first week of oral feeds. Babies of 34 to 37 weeks' gestation achieved a 'mature' intestinal permeability to lactulose within four days of starting oral feeds. These findings may reflect the immaturity of the gut of the preterm baby rather than a process essential to adaptation to enteral nutrition.
采用含有乳果糖和甘露醇的喂养方式，对33名新生儿的肠道被动通透性进行了研究。人们认为每种标记物通过不同途径穿过肠壁；乳果糖通过细胞旁途径，甘露醇通过跨细胞途径。两者均不被代谢，且都完全由肾脏排泄；尿回收率是肠道摄取的一个指标。孕34周前出生的婴儿对乳果糖的肠道通透性高于足月婴儿，所有早产儿在开始口服喂养的第一周内乳果糖吸收均有明显下降。孕34至37周的婴儿在开始口服喂养的四天内达到了对乳果糖的“成熟”肠道通透性。这些发现可能反映了早产儿肠道的不成熟，而非适应肠内营养所必需的过程。
