Wattanavijitkul Thitima, Khamwannah Jirapon, Lohwongwatana Boonrat, Puncreobutr Chedtha, Reddy Narendra, Yamdech Rungnapha, Cherdchom Sarocha, Aramwit Pornanong
Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences and Center of Excellence in Bioactive Resources for Innovative Clinical Applications, Chulalongkorn University, Bangkok 10330, Thailand.
Department of Metallurgical Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok 10330, Thailand.
ACS Omega. 2024 Aug 22;9(35):37052-37062. doi: 10.1021/acsomega.4c03942. eCollection 2024 Sep 3.
This study investigates the utilization of poly(vinyl alcohol) (PVA)/gelatin hydrogel films cross-linked with glutaraldehyde as a novel material to coat the surface of vancomycin-loaded titania nanotubes (TNTs), with a focus on enhancing biocompatibility and achieving controlled vancomycin release. Hydrogel films have emerged as promising candidates in tissue engineering and drug-delivery systems due to their versatile properties. The development of these hydrogel films involved varying the proportions of PVA, gelatin, and glutaraldehyde to achieve the desired properties, including the gel fraction, swelling behavior, biocompatibility, and biodegradation. Among the formulations tested, the hydrogel with a PVA-to-gelatin ratio of 25:75 and 0.2% glutaraldehyde was selected to coat vancomycin-loaded TNTs. The coated TNTs demonstrated slower release of vancomycin compared with the uncoated TNTs. In addition, the coated TNTs demonstrated the ability to promote osteogenesis, as evidenced by increased alkaline phosphatase activity and calcium accumulation. The vancomycin-loaded TNTs coated with hydrogel film demonstrated effectiveness against both and . These findings highlight the potential benefits and therapeutic applications of using hydrogel films to coat implant materials, offering efficient drug delivery and controlled release. This study contributes valuable insights into the development of alternative materials for medical applications, thereby advancing the field of biomaterials and drug delivery systems.
本研究考察了用戊二醛交联的聚乙烯醇（PVA）/明胶水凝胶薄膜作为一种新型材料来包覆负载万古霉素的二氧化钛纳米管（TNTs）表面的情况，重点是提高生物相容性并实现万古霉素的控释。水凝胶薄膜因其多样的特性已成为组织工程和药物递送系统中有前景的候选材料。这些水凝胶薄膜的开发涉及改变PVA、明胶和戊二醛的比例以实现所需特性，包括凝胶分数、溶胀行为、生物相容性和生物降解性。在所测试的配方中，选择了PVA与明胶比例为25:75且含有0.2%戊二醛的水凝胶来包覆负载万古霉素的TNTs。与未包覆的TNTs相比，包覆后的TNTs显示出万古霉素释放较慢。此外，包覆后的TNTs显示出促进成骨的能力，碱性磷酸酶活性增加和钙积累证明了这一点。包覆有水凝胶薄膜的负载万古霉素的TNTs对 和 均显示出有效性。这些发现突出了用水凝胶薄膜包覆植入材料的潜在益处和治疗应用，提供了高效的药物递送和控释。本研究为医疗应用替代材料的开发提供了有价值的见解，从而推动了生物材料和药物递送系统领域的发展。
