ARC Centre of Excellence for Electromaterials Science and Intelligent Polymer Research Institute, University of Wollongong, Innovation Campus, Squires Way, North Wollongong, NSW 2522, Australia.
State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, P. R. China.
ACS Appl Bio Mater. 2021 Apr 19;4(4):2886-2906. doi: 10.1021/acsabm.0c01630. Epub 2021 Mar 9.
Gelatin based hydrogels are often incorporated with supporting materials such as chitosan, poly(vinyl alcohol), alginate, carbon nanotubes, and hyaluronic acid. These hybrid materials are specifically of interest in diversified nanomedicine fields as they exhibit unique physicochemical properties, antimicrobial activity, biodegradability, and biocompatibility. The applications include drug delivery, wound healing, cell culture, and tissue engineering. This paper reviews the various up-to-date methods to fabricate gelatin-based hydrogels, including UV photo-cross-linking, electrospinning, and 3D bioprinting. This paper also includes physical, chemical, mechanical, and biocompatibility characterization studies of several hybrid gelatin hydrogels and discusses their relevance in nanomedicine based applications. Challenges associated with the fabrication of hybrid materials for nanotechnology implementation, specifically in nanomedicine development, are critically discussed, and some future recommendations are provided.
基于明胶的水凝胶通常与壳聚糖、聚乙烯醇、海藻酸盐、碳纳米管和透明质酸等支持材料结合使用。这些混合材料在多样化的纳米医学领域特别感兴趣，因为它们具有独特的物理化学性质、抗菌活性、生物降解性和生物相容性。其应用包括药物输送、伤口愈合、细胞培养和组织工程。本文综述了各种最新的制备基于明胶的水凝胶的方法，包括紫外光交联、静电纺丝和 3D 生物打印。本文还包括对几种混合明胶水凝胶的物理、化学、机械和生物相容性特性研究，并讨论了它们在基于纳米医学的应用中的相关性。本文还批判性地讨论了与纳米技术实施相关的混合材料制备面临的挑战，特别是在纳米医学发展方面，并提供了一些未来的建议。
