白细胞介素2上调其在T细胞克隆上的受体表达。
Interleukin 2 upregulates expression of its receptor on a T cell clone.
作者信息
Malek T R, Ashwell J D
出版信息
J Exp Med. 1985 Jun 1;161(6):1575-80. doi: 10.1084/jem.161.6.1575.
Abstract
Stimulation of a class II-restricted, antigen-specific T cell clone with interleukin 2 (IL-2) resulted in substantial increases in both cell surface IL-2 receptor (IL-2-R) and cytoplasmic IL-2-R messenger RNA (mRNA), whereas no increase was observed for cell-surface expression of Thy-1 and L3T4 antigens, and only a modest increase in Thy-1 mRNA was observed. These experiments demonstrate that, after initial acquisition of the IL-2-R, IL-2 as well as antigen is able to directly upregulate both the level of IL-2-R mRNA and cell surface IL-2-R molecules.
摘要
用白细胞介素2（IL-2）刺激一个受II类分子限制的、抗原特异性T细胞克隆，导致细胞表面IL-2受体（IL-2-R）和细胞质IL-2-R信使核糖核酸（mRNA）都大幅增加，而Thy-1和L3T4抗原的细胞表面表达未增加，仅观察到Thy-1 mRNA有适度增加。这些实验表明，在最初获得IL-2-R后，IL-2以及抗原能够直接上调IL-2-R mRNA水平和细胞表面IL-2-R分子。
相似文献
1
Interleukin 2 upregulates expression of its receptor on a T cell clone.白细胞介素2上调其在T细胞克隆上的受体表达。
J Exp Med. 1985 Jun 1;161(6):1575-80. doi: 10.1084/jem.161.6.1575.
2
Induction of receptors for interleukin 2 requires T cell Ag:Ia receptor crosslinking and interleukin 1.白细胞介素2受体的诱导需要T细胞抗原：Ia受体交联和白细胞介素1。
Lymphokine Res. 1984 Summer;3(4):175-82.
3
4
5
Activation of T cells by interleukin 1 involves internalization of interleukin 1.白细胞介素 1 对 T 细胞的激活涉及白细胞介素 1 的内化。
Lymphokine Res. 1989 Fall;8(3):263-8.
6
Proliferation of T lymphocytes in response to interleukin 2 varies with their state of activation.T淋巴细胞对白介素2的反应性增殖随其激活状态而变化。
J Immunol. 1986 Oct 15;137(8):2572-8.
7
Involvement of soluble mediator(s) different from interleukin (IL) 1 in the antigen-induced IL 2 receptor expression and proliferation of L3T4+ (CD4+) T lymphocytes.
Eur J Immunol. 1988 Mar;18(3):459-65. doi: 10.1002/eji.1830180321.
8
[Human interleukin 2].[人白细胞介素2]
Ann Immunol (Paris). 1983 Sep-Oct;134D(2):157-65.
9
Characterization of two distinct primary T cell populations that secrete interleukin 2 upon recognition of class I or class II major histocompatibility antigens.两种不同的初始T细胞群体的特征，这两种群体在识别I类或II类主要组织相容性抗原后会分泌白细胞介素2 。
J Exp Med. 1986 Mar 1;163(3):603-19. doi: 10.1084/jem.163.3.603.
10
B cells as accessory cells in a Con A response of a T cell clone.B细胞作为T细胞克隆的伴刀豆球蛋白A反应中的辅助细胞。
Immunobiology. 1987 Dec;176(1-2):1-13. doi: 10.1016/S0171-2985(87)80095-5.
引用本文的文献
1
A novel anti-human CD25 mAb with preferential reactivity to activated T regulatory cells depletes them from the tumor microenvironment.一种对活化的调节性T细胞具有优先反应性的新型抗人CD25单克隆抗体可将它们从肿瘤微环境中清除。
Oncotarget. 2025 Jul 9;16:545-558. doi: 10.18632/oncotarget.28752.
2
Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4 T cell perturbations.单细胞分析人类和小鼠中的 FOXP3 缺陷，揭示了内在和外在 CD4 T 细胞的扰动。
Nat Immunol. 2021 May;22(5):607-619. doi: 10.1038/s41590-021-00910-8. Epub 2021 Apr 8.
3
Persistent IL-2 Receptor Signaling by IL-2/CD25 Fusion Protein Controls Diabetes in NOD Mice by Multiple Mechanisms.IL-2/CD25 融合蛋白通过持续的 IL-2 受体信号传导通过多种机制控制 NOD 小鼠的糖尿病。
Diabetes. 2020 Nov;69(11):2400-2413. doi: 10.2337/db20-0186. Epub 2020 Aug 25.
4
Altered homeostasis and development of regulatory T cell subsets represent an IL-2R-dependent risk for diabetes in NOD mice.调节性 T 细胞亚群的平衡和发育的改变代表 NOD 小鼠中 IL-2R 依赖性糖尿病风险。
Sci Signal. 2017 Dec 19;10(510):eaam9563. doi: 10.1126/scisignal.aam9563.
5
Therapeutic efficacy of monthly subcutaneous injection of daclizumab in relapsing multiple sclerosis.每月皮下注射达利珠单抗治疗复发型多发性硬化症的疗效。
Biologics. 2016 Sep 12;10:119-38. doi: 10.2147/BTT.S89218. eCollection 2016.
6
CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets.CCR7 提供了对 IL-2 的局部获取，并定义了具有不同稳态的调节性 T 细胞亚群。
J Exp Med. 2014 Jan 13;211(1):121-36. doi: 10.1084/jem.20131142. Epub 2013 Dec 30.
7
IL-2R signaling is essential for functional maturation of regulatory T cells during thymic development.白细胞介素-2 受体信号对于调节性 T 细胞在胸腺发育过程中的功能成熟是必需的。
J Immunol. 2013 Feb 15;190(4):1567-75. doi: 10.4049/jimmunol.1201218. Epub 2013 Jan 11.
8
Transient enhanced IL-2R signaling early during priming rapidly amplifies development of functional CD8+ T effector-memory cells.在初始阶段早期短暂增强的 IL-2R 信号会迅速扩增功能性 CD8+ T 效应记忆细胞的发育。
J Immunol. 2012 Nov 1;189(9):4321-30. doi: 10.4049/jimmunol.1202067. Epub 2012 Sep 26.
9
IL-2 receptor signaling is essential for the development of Klrg1+ terminally differentiated T regulatory cells.IL-2 受体信号对于 Klrg1+终末分化的 T 调节细胞的发育是必不可少的。
J Immunol. 2012 Aug 15;189(4):1780-91. doi: 10.4049/jimmunol.1103768. Epub 2012 Jul 11.
10
Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation.TNFRSF25 通过扩增调节性 T 细胞防止小鼠变应性肺炎症。
J Clin Invest. 2010 Oct;120(10):3629-40. doi: 10.1172/JCI42933. Epub 2010 Sep 20.
本文引用的文献
1
A monoclonal antibody discriminating between subsets of T and B cells.一种可区分T细胞和B细胞亚群的单克隆抗体。
J Immunol. 1981 Dec;127(6):2496-501.
2
Monoclonal antibodies against rat immunoglobulin kappa chains.抗大鼠免疫球蛋白κ链单克隆抗体。
Hybridoma. 1982;1(2):125-31. doi: 10.1089/hyb.1.1982.1.125.
3
Mouse immunoglobulin D: construction and characterization of a cloned delta chain cDNA.小鼠免疫球蛋白D：克隆的δ链cDNA的构建与表征
Proc Natl Acad Sci U S A. 1980 Dec;77(12):7405-9. doi: 10.1073/pnas.77.12.7405.
4
Antigen presentation by resting B cells. Radiosensitivity of the antigen-presentation function and two distinct pathways of T cell activation.静息B细胞的抗原呈递。抗原呈递功能的放射敏感性及T细胞活化的两条不同途径。
J Exp Med. 1984 Mar 1;159(3):881-905. doi: 10.1084/jem.159.3.881.
5
Purification and partial sequence analysis of human T-cell growth factor.人T细胞生长因子的纯化及部分序列分析
Proc Natl Acad Sci U S A. 1983 Oct;80(19):5990-4. doi: 10.1073/pnas.80.19.5990.
6
Interleukin 2 regulates expression of its receptor and synthesis of gamma interferon by human T lymphocytes.白细胞介素2调节其受体的表达以及人T淋巴细胞γ干扰素的合成。
Science. 1984 Jul 27;225(4660):429-30. doi: 10.1126/science.6429853.
7
Identification and initial characterization of a rat monoclonal antibody reactive with the murine interleukin 2 receptor-ligand complex.一种与小鼠白细胞介素2受体-配体复合物反应的大鼠单克隆抗体的鉴定及初步表征。
Proc Natl Acad Sci U S A. 1983 Sep;80(18):5694-8. doi: 10.1073/pnas.80.18.5694.
8
Biological activity of recombinant human interleukin-2 produced in Escherichia coli.在大肠杆菌中产生的重组人白细胞介素-2的生物活性。
Science. 1984 Mar 30;223(4643):1412-4. doi: 10.1126/science.6367046.
9
Isolation of cDNA clones encoding T cell-specific membrane-associated proteins.编码T细胞特异性膜相关蛋白的cDNA克隆的分离
Nature. 1984;308(5955):149-53. doi: 10.1038/308149a0.
10
Characterization of the murine antigenic determinant, designated L3T4a, recognized by monoclonal antibody GK1.5: expression of L3T4a by functional T cell clones appears to correlate primarily with class II MHC antigen-reactivity.被单克隆抗体GK1.5识别的、命名为L3T4a的鼠类抗原决定簇的特性：功能性T细胞克隆对L3T4a的表达似乎主要与II类主要组织相容性复合体（MHC）抗原反应性相关。
Immunol Rev. 1983;74:29-56. doi: 10.1111/j.1600-065x.1983.tb01083.x.
Zotero 插件