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1
Interleukin 2 upregulates expression of its receptor on a T cell clone.白细胞介素2上调其在T细胞克隆上的受体表达。
J Exp Med. 1985 Jun 1;161(6):1575-80. doi: 10.1084/jem.161.6.1575.
2
Induction of receptors for interleukin 2 requires T cell Ag:Ia receptor crosslinking and interleukin 1.白细胞介素2受体的诱导需要T细胞抗原：Ia受体交联和白细胞介素1。
Lymphokine Res. 1984 Summer;3(4):175-82.
3
Antigen-specific murine T cell clones produce soluble interleukin 2 receptor on stimulation with specific antigens.抗原特异性小鼠T细胞克隆在受到特异性抗原刺激时会产生可溶性白细胞介素2受体。
J Immunol. 1986 Jul 15;137(2):592-6.
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The murine IL 2 receptor. III. Cellular requirements for the induction of IL 2 receptor expression on T cell subpopulations.小鼠白细胞介素2受体。III. T细胞亚群上白细胞介素2受体表达诱导的细胞需求。
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Activation of T cells by interleukin 1 involves internalization of interleukin 1.白细胞介素 1 对 T 细胞的激活涉及白细胞介素 1 的内化。
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本文引用的文献

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A monoclonal antibody discriminating between subsets of T and B cells.一种可区分T细胞和B细胞亚群的单克隆抗体。
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Monoclonal antibodies against rat immunoglobulin kappa chains.抗大鼠免疫球蛋白κ链单克隆抗体。
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Interleukin 2 regulates expression of its receptor and synthesis of gamma interferon by human T lymphocytes.白细胞介素2调节其受体的表达以及人T淋巴细胞γ干扰素的合成。
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10
Characterization of the murine antigenic determinant, designated L3T4a, recognized by monoclonal antibody GK1.5: expression of L3T4a by functional T cell clones appears to correlate primarily with class II MHC antigen-reactivity.被单克隆抗体GK1.5识别的、命名为L3T4a的鼠类抗原决定簇的特性：功能性T细胞克隆对L3T4a的表达似乎主要与II类主要组织相容性复合体（MHC）抗原反应性相关。
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白细胞介素2上调其在T细胞克隆上的受体表达。

Interleukin 2 upregulates expression of its receptor on a T cell clone.

作者信息

Malek T R, Ashwell J D

出版信息

J Exp Med. 1985 Jun 1;161(6):1575-80. doi: 10.1084/jem.161.6.1575.

DOI:10.1084/jem.161.6.1575
PMID:3925066
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2187624/
Abstract

Stimulation of a class II-restricted, antigen-specific T cell clone with interleukin 2 (IL-2) resulted in substantial increases in both cell surface IL-2 receptor (IL-2-R) and cytoplasmic IL-2-R messenger RNA (mRNA), whereas no increase was observed for cell-surface expression of Thy-1 and L3T4 antigens, and only a modest increase in Thy-1 mRNA was observed. These experiments demonstrate that, after initial acquisition of the IL-2-R, IL-2 as well as antigen is able to directly upregulate both the level of IL-2-R mRNA and cell surface IL-2-R molecules.

摘要

用白细胞介素2（IL-2）刺激一个受II类分子限制的、抗原特异性T细胞克隆，导致细胞表面IL-2受体（IL-2-R）和细胞质IL-2-R信使核糖核酸（mRNA）都大幅增加，而Thy-1和L3T4抗原的细胞表面表达未增加，仅观察到Thy-1 mRNA有适度增加。这些实验表明，在最初获得IL-2-R后，IL-2以及抗原能够直接上调IL-2-R mRNA水平和细胞表面IL-2-R分子。