Bruzzone M S, Minguell J J
Acta Haematol. 1985;73(2):75-9. doi: 10.1159/000206284.
Fibroblast-like cells were grown from the bone marrow of acute lymphoblastic leukemia (ALL) patients before, during and off therapy. A diminished growth capacity was observed in cells from patients before and during therapy. In the three groups studied, differences were also observed in the effect of hydrocortisone on DNA synthesis and in the content of glucocorticoid binding sites. These results suggest that microenvironmental changes occur in ALL, which may revert to normality during or after therapy.
从急性淋巴细胞白血病（ALL）患者治疗前、治疗期间及治疗结束后的骨髓中培养出成纤维细胞样细胞。观察到治疗前及治疗期间患者的细胞生长能力下降。在所研究的三组中，还观察到氢化可的松对DNA合成的影响以及糖皮质激素结合位点含量的差异。这些结果表明，ALL中发生了微环境变化，在治疗期间或治疗后可能恢复正常。
