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组胺在体外可降低腐胺的脱氨作用——但在体内也是如此吗?

Histamine reduces the deamination of putrescine in vitro--but also in vivo?

作者信息

Kusche J, Mennigen R, Rosenthal I

出版信息

Agents Actions. 1985 Apr;16(3-4):102-4. doi: 10.1007/BF01983112.

DOI:10.1007/BF01983112
PMID:3925731
Abstract

The diamine oxidase catalysed deamination of putrescine was reduced in vitro by histamine at concentrations occurring in the gut. An oral application of histamine, however, had no effect on the enzymic activity. When the histamine was injected i.p. a decrease of intestinal diamine oxidase activity was observed which, however, did not depend on histamine but probably on an unspecific irritation of the gut.

摘要

在体外,肠道中存在的组胺浓度可降低二胺氧化酶催化的腐胺脱氨作用。然而,口服组胺对酶活性没有影响。当腹腔注射组胺时,观察到肠道二胺氧化酶活性降低,但这可能并非取决于组胺,而是可能由于肠道的非特异性刺激。

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Histamine reduces the deamination of putrescine in vitro--but also in vivo?组胺在体外可降低腐胺的脱氨作用——但在体内也是如此吗?
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引用本文的文献

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Histamine content, diamine oxydase and histidine decarboxylase activities along the intestinal tract of the rat.大鼠肠道中组胺含量、二胺氧化酶和组氨酸脱羧酶的活性
Agents Actions. 1989 Nov;28(3-4):231-4. doi: 10.1007/BF01967407.
2
Histaminase activity in rat lung and its comparison with intestinal mucosal diamine oxidase.大鼠肺组织中的组胺酶活性及其与肠黏膜二胺氧化酶的比较。
Agents Actions. 1992 Mar;35(3-4):192-9. doi: 10.1007/BF01997499.

本文引用的文献

1
N-methyl-N-formylhydrazine: a toxic and mutagenic inhibitor of the intestinal diamine oxidase.N-甲基-N-甲酰肼:一种对肠道二胺氧化酶具有毒性和致突变性的抑制剂。
Agents Actions. 1984 Apr;14(3-4):351-5. doi: 10.1007/BF01973825.
2
Intestinal diamine oxidase and histamine release in rabbit mesenteric ischemia.兔肠系膜缺血时肠道二胺氧化酶与组胺释放
Gastroenterology. 1981 May;80(5 pt 1):980-7.
3
A sensitive and specific method for the determination of histomine in human whole blood and plasma.一种测定人全血和血浆中组胺的灵敏且特异的方法。
Hoppe Seylers Z Physiol Chem. 1972 Jun;353(6):911-20. doi: 10.1515/bchm2.1972.353.1.911.
4
Increased diamine oxidase activity in the intestinal lymph of rats on fat ingestion.摄入脂肪的大鼠肠淋巴中二胺氧化酶活性增加。
Can J Physiol Pharmacol. 1974 Jun;52(3):760-2. doi: 10.1139/y74-099.
5
The influence of histamine on epithelial cell proliferation in the jejunum of the rat.
Clin Exp Pharmacol Physiol. 1976 Jul-Aug;3(4):369-73. doi: 10.1111/j.1440-1681.1976.tb00613.x.