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Relationship between the hsa miR 150-5p and FTO gene expression in white subcutaneous adipose tissue with overweight/obesity, lipid profile and glycemia.
An Acad Bras Cienc. 2020 Nov 20;92(4):e20200249. doi: 10.1590/0001-3765202020200249. eCollection 2020.
2
The association between FTO genotype with macronutrients and calorie intake in overweight adults.超重成年人中 FTO 基因型与宏量营养素和卡路里摄入的关系。
Lipids Health Dis. 2020 Aug 26;19(1):197. doi: 10.1186/s12944-020-01372-x.
3
Prevalence and Incidence of Metabolic Syndrome in Iran: A Systematic Review and Meta-Analysis.伊朗代谢综合征的患病率与发病率：一项系统评价与荟萃分析
Int J Prev Med. 2020 Jun 3;11:64. doi: 10.4103/ijpvm.IJPVM_489_18. eCollection 2020.
4
Association of rs9939609 polymorphism with serum leptin, insulin, adiponectin, and lipid profile in overweight adults.rs9939609 多态性与超重成年人血清瘦素、胰岛素、脂联素和血脂谱的关联。
Adipocyte. 2020 Dec;9(1):51-56. doi: 10.1080/21623945.2020.1722550.
5
Metabolic health in the Middle East and north Africa.中东和北非的代谢健康。
Lancet Diabetes Endocrinol. 2019 Nov;7(11):866-879. doi: 10.1016/S2213-8587(19)30179-2. Epub 2019 Aug 14.
6
Relationship Between Fat Mass and Obesity-Associated (FTO) Gene Polymorphisms with Obesity and Metabolic Syndrome in Ethnic Mongolians.蒙古族人群脂肪质量和肥胖相关基因（FTO）多态性与肥胖及代谢综合征的关系。
Med Sci Monit. 2018 Nov 16;24:8232-8238. doi: 10.12659/MSM.910928.
7
Fat Mass and Obesity Associated () Gene and Hepatic Glucose and Lipid Metabolism.脂肪量和肥胖相关基因与肝脏葡萄糖和脂质代谢。
Nutrients. 2018 Nov 1;10(11):1600. doi: 10.3390/nu10111600.
8
The prevalence and risk factors of dyslipidemia in different diabetic progression stages among middle-aged and elderly populations in China.中国中老年人群不同糖尿病进展阶段血脂异常的患病率及相关危险因素。
PLoS One. 2018 Oct 16;13(10):e0205709. doi: 10.1371/journal.pone.0205709. eCollection 2018.
9
Lipidomic insight into cardiovascular diseases.脂质组学与心血管疾病研究进展
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The Global Epidemic of the Metabolic Syndrome.代谢综合征的全球流行。
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成人女性中FTO rs9939609基因多态性与血脂谱的关联

The association between FTO rs9939609 polymorphism and serum lipid profile in adult women.

作者信息

Jalili Vahideh, Mokhtari Zohreh, Rastgoo Samira, Hajipour Azadeh, Bourbour Fatemeh, Gholamalizadeh Maryam, Mosavi Jarrahi Alireza, JavadiKooshesh Sepehr, Moslem Alireza, Abdollahi Morteza, Doaei Saeid

机构信息

Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.

Department of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Diabetol Metab Syndr. 2021 Nov 20;13(1):138. doi: 10.1186/s13098-021-00754-0.

DOI:10.1186/s13098-021-00754-0
PMID:34801066
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8606052/
Abstract

BACKGROUND

FTO gene is considered to play an important role in many metabolic diseases. Evidence from studies indicated the possible association between the FTO rs9939609 polymorphisms with serum lipid profile. Therefore, this study aimed to investigate the association of FTO rs9939609 polymorphism with lipid profile in Iranian women.

METHODS

This cross-sectional study was carried out on 380 adult women. Information about age, height, weight, BMI, physical activity, and dietary intake were collected. The serum levels of Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL), Triglyceride (TG), and total cholesterol were measured. The FTO gene was genotyped for rs9939609 polymorphism. The participants were divided into two groups of TT and AT/AA considering dominant model of FTO rs9939609 polymorphism.

RESULTS

General characteristics of the participants with different FTO genotypes were not significantly different. The lower levels of HDL were observed in AT/AA genotypes compared to the TT wild type genotype of FTO rs9939609 polymorphism (P = 0.004). Adjustments of age, BMI, and physical activity did not change the results.

CONCLUSIONS

However, the significant association between FTO genotype and the HDL level was disappeared after further adjustments for dietary intake. Further studies are warranted to identify the underlying mechanisms of the possible association between FTO gene and serum lipid profile.

摘要

背景

FTO基因被认为在多种代谢性疾病中起重要作用。研究证据表明FTO rs9939609多态性与血脂谱之间可能存在关联。因此，本研究旨在调查伊朗女性中FTO rs9939609多态性与血脂谱的关联。

方法

本横断面研究对380名成年女性进行。收集了年龄、身高、体重、BMI、身体活动和饮食摄入等信息。测量了血清低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、甘油三酯（TG）和总胆固醇水平。对FTO基因进行rs9939609多态性基因分型。根据FTO rs9939609多态性的显性模型，将参与者分为TT组和AT/AA组。

结果

不同FTO基因型参与者的一般特征无显著差异。与FTO rs9939609多态性的TT野生型基因型相比，AT/AA基因型的HDL水平较低（P = 0.004）。年龄、BMI和身体活动的调整并未改变结果。

结论

然而，在对饮食摄入进行进一步调整后，FTO基因型与HDL水平之间的显著关联消失。有必要进行进一步研究以确定FTO基因与血脂谱之间可能关联的潜在机制。