Lichtenstein M J, Shipley M J, Rose G
Br Med J (Clin Res Ed). 1985 Jul 27;291(6490):243-5. doi: 10.1136/bmj.291.6490.243.
Systolic and diastolic blood pressures were compared as predictors of death due to coronary heart disease using data on the 10 year mortality outcome from the 18 403 male civil servants, aged 40-64, in the Whitehall study. There were 727 deaths due to coronary heart disease. At entry to the study the systolic pressure in these men was significantly higher than the diastolic pressure, and a standardised index of relative risk for death from coronary heart disease was greater for systolic blood pressure. After adjustment for age the top quintile of systolic pressure (greater than 151 mm Hg) identified 5% more men at risk of death from coronary heart disease than for the top diastolic quintile (greater than 95 mm Hg). The findings suggested that clinicians should pay more attention to systolic levels as a criterion for making diagnostic and therapeutic decisions.
利用白厅研究中18403名年龄在40 - 64岁的男性公务员10年死亡率的数据，比较收缩压和舒张压作为冠心病死亡预测指标的情况。冠心病死亡人数为727人。在研究开始时，这些男性的收缩压显著高于舒张压，且冠心病死亡相对风险的标准化指数收缩压更高。在调整年龄后，收缩压最高五分位数（大于151毫米汞柱）比舒张压最高五分位数（大于95毫米汞柱）多识别出5%有冠心病死亡风险的男性。研究结果表明，临床医生在做出诊断和治疗决策时，应更多地关注收缩压水平作为一项标准。
