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在强毒力肺炎支原体的非血细胞吸附群体中检测肺炎支原体黏附素（P1）

Detection of Mycoplasma pneumoniae adhesin (P1) in the nonhemadsorbing population of virulent Mycoplasma pneumoniae.

作者信息

Kahane I, Tucker S, Baseman J B

出版信息

Infect Immun. 1985 Aug;49(2):457-8. doi: 10.1128/iai.49.2.457-458.1985.

DOI:10.1128/iai.49.2.457-458.1985
PMID:3926653
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC262042/
Abstract

Mycoplasma pneumoniae organisms possessing a hemadsorbing-negative (HA-) phenotype comprise more than 50% of the population of virulent M. pneumoniae cultures. Monoclonal antibody to P1, the major adhesin of M. pneumoniae reacts with this HA- mycoplasma fraction based upon radioimmunoprecipitation and immunoblotting. Demonstration of P1 in the entire mycoplasma population suggests that topological organization of this adhesin in the membrane or the physiological state of the mycoplasmas may determine hemadsorbing capabilities.

摘要

具有血吸附阴性（HA-）表型的肺炎支原体菌株占致病性肺炎支原体培养群体的50%以上。基于放射免疫沉淀和免疫印迹分析，针对肺炎支原体主要黏附素P1的单克隆抗体可与该HA-支原体组分发生反应。在整个支原体群体中检测到P1表明，这种黏附素在膜中的拓扑结构或支原体的生理状态可能决定其血吸附能力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad96/262042/60f4685a7bfc/iai00113-0210-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad96/262042/f9835dadd7f2/iai00113-0209-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad96/262042/60f4685a7bfc/iai00113-0210-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad96/262042/f9835dadd7f2/iai00113-0209-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ad96/262042/60f4685a7bfc/iai00113-0210-a.jpg

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Detection of Mycoplasma pneumoniae adhesin (P1) in the nonhemadsorbing population of virulent Mycoplasma pneumoniae.在强毒力肺炎支原体的非血细胞吸附群体中检测肺炎支原体黏附素（P1）
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引用本文的文献

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2
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The principal protein antigens of isolates of Mycoplasma pneumoniae as measured by levels of immunoglobulin G in human serum are stable in strains collected over a 10-year period.通过人血清中免疫球蛋白G水平测定的肺炎支原体分离株的主要蛋白质抗原，在10年期间收集的菌株中是稳定的。

本文引用的文献

1
Mycoplasma pneumoniae adhesin localized to tip structure by monoclonal antibody.肺炎支原体黏附素通过单克隆抗体定位于顶端结构。
Nature. 1982 Aug 19;298(5876):765-7. doi: 10.1038/298765a0.
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Sialic acid residues mediate Mycoplasma pneumoniae attachment to human and sheep erythrocytes.唾液酸残基介导肺炎支原体与人及绵羊红细胞的黏附。
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Isolation of binding sites to glycophorin from Mycoplasma pneumoniae membranes.从肺炎支原体膜中分离与血型糖蛋白的结合位点
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Purification of a Mycoplasma pneumoniae adhesin by monoclonal antibody affinity chromatography.通过单克隆抗体亲和层析法纯化肺炎支原体粘附素
J Bacteriol. 1984 Feb;157(2):678-80. doi: 10.1128/jb.157.2.678-680.1984.
8
Inhibition of mycoplasma pneumoniae hemadsorption and adherence to respiratory epithelium by antibodies to a membrane protein.抗膜蛋白抗体对肺炎支原体血细胞吸附及黏附于呼吸道上皮的抑制作用。
Infect Immun. 1983 Mar;39(3):1180-6. doi: 10.1128/iai.39.3.1180-1186.1983.
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Reacquisition of specific proteins confers virulence in Mycoplasma pneumoniae.特定蛋白质的重新获得赋予肺炎支原体毒力。
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Host discrimination of Mycoplasma pneumoniae proteinaceous immunogens.宿主对肺炎支原体蛋白质免疫原的识别。
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