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环状 RNA:缺血性脑卒中的新靶点。

CircRNA: A new target for ischemic stroke.

机构信息

Hunan University of Traditional Chinese Medicine, Changsha, Hunan 410208, China.

The first affiliated hospital of hunan university of Chinese medicine, Changsha 410007, China.

出版信息

Gene. 2025 Jan 15;933:148941. doi: 10.1016/j.gene.2024.148941. Epub 2024 Sep 11.

Abstract

Ischemic stroke, a clinical emergency and disease with a poor prognosis, has a negative impact on the survival index of patients. It is frequently precipitated by a multitude of risk factors, including trauma. Currently, there is a paucity of predictive indicators for early intervention. As stable and abundant RNA in the body, circRNAs play a regulatory role in miRNAs and proteins, which affect the occurrence and development of diseases. Moreover, circRNAs can serve as predictors of clinical diseases. Several studies have demonstrated that circRNAs play pivotal roles in numerous aspects of ischemic stroke. Consequently, circRNAs have emerged as key areas of investigation in the field of ischemic stroke.

摘要

缺血性脑卒中是一种临床急症和预后不良的疾病,对患者的生存指数有负面影响。它常由多种危险因素诱发,包括创伤。目前,早期干预的预测指标较少。环状 RNA 是体内稳定且丰富的 RNA,在 miRNA 和蛋白质中发挥调控作用,影响疾病的发生和发展。此外,环状 RNA 可以作为临床疾病的预测指标。多项研究表明,环状 RNA 在缺血性脑卒中的许多方面发挥着关键作用。因此,环状 RNA 已成为缺血性脑卒中领域的研究热点。

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