Buzdağlı Yusuf, Eyipınar Cemre Didem, Kacı Fatma Necmiye, Tekin Aslıhan
Department of Coaching Education, Faculty of Sport Sciences, Erzurum Technical University, Erzurum, Turkey.
Department of Physical Education and Sports, Faculty of Sports Sciences, Gaziantep University, Gaziantep, Turkey.
Int J Environ Health Res. 2023 Dec;33(12):1390-1405. doi: 10.1080/09603123.2022.2093841. Epub 2022 Jun 28.
Hesperidin is a prominent flavanone found in citrus fruits that has a broad range of biological effects, including anti-inflammatory and antioxidant capabilities. The study's objective was to evaluate the effects of hesperidin supplementation on anti-inflammatory and antioxidant parameters such as MDA, TAC, GSH, SOD, and CAT; CRP, TNF-α, IL-6, and IL-4 levels respectively, by analyzing human intervention trials. Google Scholar, PubMed, grey literature databases, and the ClinicalTrials website were scanned to identify eligible studies. For the meta-analysis, eighteen studies were chosen. Hesperidin supplementation had significant lowering effect on not only CRP, IL-6, and IL-4 levels but also MDA level (Meta-regression analysis revealed a non-significant direct relationship between hesperidin dosage and chance in CRP, IL-6, and MDA levels. As a result, it can be said that hesperidin supplementation contributes to the inflammatory and antioxidant response, but this contribution is independent of dosage.
橙皮苷是柑橘类水果中一种重要的黄烷酮，具有广泛的生物学效应，包括抗炎和抗氧化能力。该研究的目的是通过分析人体干预试验，评估补充橙皮苷对诸如丙二醛（MDA）、总抗氧化能力（TAC）、谷胱甘肽（GSH）、超氧化物歧化酶（SOD）和过氧化氢酶（CAT）等抗炎和抗氧化参数，以及分别对C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和白细胞介素-4（IL-4）水平的影响。检索了谷歌学术、PubMed、灰色文献数据库和临床试验网站以确定符合条件的研究。为进行荟萃分析，选择了18项研究。补充橙皮苷不仅对CRP、IL-6和IL-4水平有显著降低作用，而且对MDA水平也有显著降低作用（Meta回归分析显示橙皮苷剂量与CRP、IL-6和MDA水平变化之间无显著直接关系。因此，可以说补充橙皮苷有助于炎症和抗氧化反应，但这种作用与剂量无关。
