Jaber Mohamed, Alshikh Ali Aalaa Majed, El Saleh Roba Imad, Prasad Prathibha
Department of Clinical Dental Sciences, College of Dentistry, Ajman University, Ajman P.O. Box 346, United Arab Emirates.
Center of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman P.O. Box 346, United Arab Emirates.
J Clin Med. 2024 Sep 8;13(17):5315. doi: 10.3390/jcm13175315.
Cleft lip alone or a combination of cleft lip and palate (CLP) is a common developmental abnormality in the craniofacial region. This umbrella review aims to identify promising avenues for treatment using stem cell therapy. Systematic reviews from 2014 to 2024 were searched among databases like PubMed, Medline, and Google Scholar. PRISMA guidelines were employed to ensure the thoroughness of the search. A quality assessment (ROBIS) of the included reviews was conducted to ensure the reliability and validity of the synthesized evidence. Five systematic reviews were selected for this umbrella review. Results show that stem cell therapy, specifically using mesenchymal stem cells (MSCs) and adipocyte stem cells (ADSCs), promotes bone regeneration in CLP deformities. Although multiple studies have established the effectiveness of diverse types of stem cells in treating CLP, important considerations including safety concerns, methodological variability, and the need for standardization have been identified. The fact that the number of relevant systematic reviews that matched our inclusion criteria was limited could affect this research's robustness and may limit the breadth and depth of evidence synthesis. Definitive conclusions could not be reached due to variation among treatments and outcomes. : The examined studies highlight the potential of stem cell therapy as a complementary approach to existing treatments for CLP. However, there are challenges that need to be addressed, including concerns regarding safety, variations in methodologies, and the need for standardization. Exploring the potential of other stem cell types may further enhance treatment outcomes for CLP patients.
单纯唇裂或唇腭裂（CLP）是颅面部常见的发育异常。本系统综述旨在确定使用干细胞疗法的有前景的治疗途径。在PubMed、Medline和谷歌学术等数据库中检索了2014年至2024年的系统综述。采用PRISMA指南以确保检索的全面性。对纳入的综述进行了质量评估（ROBIS），以确保综合证据的可靠性和有效性。本系统综述选择了五项系统综述。结果表明，干细胞疗法，特别是使用间充质干细胞（MSCs）和脂肪干细胞（ADSCs），可促进CLP畸形中的骨再生。尽管多项研究已证实不同类型的干细胞在治疗CLP方面的有效性，但已确定了一些重要的考虑因素，包括安全问题、方法学变异性和标准化需求。符合我们纳入标准的相关系统综述数量有限这一事实可能会影响本研究的稳健性，并可能限制证据综合的广度和深度。由于治疗方法和结果存在差异，无法得出明确结论。所审查的研究强调了干细胞疗法作为CLP现有治疗方法的补充方法的潜力。然而，仍有一些挑战需要解决，包括对安全性的担忧、方法学的差异以及标准化的需求。探索其他干细胞类型的潜力可能会进一步提高CLP患者的治疗效果。
